Association between pulse pressure and progression of chronic kidney disease

Association between pulse pressure and progression of chronic kidney disease

Abstract The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Toshiki Maeda, Soichiro Yokota, Takumi Nishi, Shunsuke Funakoshi, Masayoshi Tsuji, Atsushi Satoh, Makiko Abe, Miki Kawazoe, Chikara Yoshimura, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Toshitaka Yamanokuchi, Kazuyo Iwanaga, Akiko Morinaga, Kaori Maki, Tamami Ueno, Kousuke Masutani, Shigeaki Mukoubara, Hisatomi Arima
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/bde9b4a1042b4e08910f25a9c24c3346
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Abstract The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identified 1042 participants who had CKD (estimated glomerular filtration rate(eGFR) < 60 mL/min/1.73 m2 or the presence of proteinuria) at baseline. Cox’s proportional hazard model was used to evaluate the association between PP and progression of CKD. During a 4.66-year mean follow-up, there were 241 cases of CKD progression (incident rate: 49.8 per 1000 person-years). A significant increase existed in CKD progression per 10 mmHg of PP elevation, even when adjusted for confounding factors [adjusted hazard ratio 1.17 (1.06–1.29) p < 0.001]. Similar results were obtained even after dividing PP into quartiles [Q2: 1.14 (0.74–1.76), Q3: 1.35 (0.88–2.06), Q4: 1.87 (1.23–2.83) p = 0.003 for trend]. This trend did not change significantly irrespective of baseline systolic or diastolic blood pressures. PP remained a potential predictive marker, especially for eGFR decline. In conclusion, we found a significant association between PP and CKD progression. PP might be a potential predictive marker for CKD progression.

Ejemplares similares