Association between pulse pressure and progression of chronic kidney disease
Abstract The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identi...
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Nature Portfolio
2021
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oai:doaj.org-article:bde9b4a1042b4e08910f25a9c24c33462021-12-05T12:13:52ZAssociation between pulse pressure and progression of chronic kidney disease10.1038/s41598-021-02809-82045-2322https://doaj.org/article/bde9b4a1042b4e08910f25a9c24c33462021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02809-8https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identified 1042 participants who had CKD (estimated glomerular filtration rate(eGFR) < 60 mL/min/1.73 m2 or the presence of proteinuria) at baseline. Cox’s proportional hazard model was used to evaluate the association between PP and progression of CKD. During a 4.66-year mean follow-up, there were 241 cases of CKD progression (incident rate: 49.8 per 1000 person-years). A significant increase existed in CKD progression per 10 mmHg of PP elevation, even when adjusted for confounding factors [adjusted hazard ratio 1.17 (1.06–1.29) p < 0.001]. Similar results were obtained even after dividing PP into quartiles [Q2: 1.14 (0.74–1.76), Q3: 1.35 (0.88–2.06), Q4: 1.87 (1.23–2.83) p = 0.003 for trend]. This trend did not change significantly irrespective of baseline systolic or diastolic blood pressures. PP remained a potential predictive marker, especially for eGFR decline. In conclusion, we found a significant association between PP and CKD progression. PP might be a potential predictive marker for CKD progression.Toshiki MaedaSoichiro YokotaTakumi NishiShunsuke FunakoshiMasayoshi TsujiAtsushi SatohMakiko AbeMiki KawazoeChikara YoshimuraKazuhiro TadaKoji TakahashiKenji ItoTetsuhiko YasunoToshitaka YamanokuchiKazuyo IwanagaAkiko MorinagaKaori MakiTamami UenoKousuke MasutaniShigeaki MukoubaraHisatomi ArimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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DOAJ |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Toshiki Maeda Soichiro Yokota Takumi Nishi Shunsuke Funakoshi Masayoshi Tsuji Atsushi Satoh Makiko Abe Miki Kawazoe Chikara Yoshimura Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Toshitaka Yamanokuchi Kazuyo Iwanaga Akiko Morinaga Kaori Maki Tamami Ueno Kousuke Masutani Shigeaki Mukoubara Hisatomi Arima Association between pulse pressure and progression of chronic kidney disease |
| description |
Abstract The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identified 1042 participants who had CKD (estimated glomerular filtration rate(eGFR) < 60 mL/min/1.73 m2 or the presence of proteinuria) at baseline. Cox’s proportional hazard model was used to evaluate the association between PP and progression of CKD. During a 4.66-year mean follow-up, there were 241 cases of CKD progression (incident rate: 49.8 per 1000 person-years). A significant increase existed in CKD progression per 10 mmHg of PP elevation, even when adjusted for confounding factors [adjusted hazard ratio 1.17 (1.06–1.29) p < 0.001]. Similar results were obtained even after dividing PP into quartiles [Q2: 1.14 (0.74–1.76), Q3: 1.35 (0.88–2.06), Q4: 1.87 (1.23–2.83) p = 0.003 for trend]. This trend did not change significantly irrespective of baseline systolic or diastolic blood pressures. PP remained a potential predictive marker, especially for eGFR decline. In conclusion, we found a significant association between PP and CKD progression. PP might be a potential predictive marker for CKD progression. |
| format |
article |
| author |
Toshiki Maeda Soichiro Yokota Takumi Nishi Shunsuke Funakoshi Masayoshi Tsuji Atsushi Satoh Makiko Abe Miki Kawazoe Chikara Yoshimura Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Toshitaka Yamanokuchi Kazuyo Iwanaga Akiko Morinaga Kaori Maki Tamami Ueno Kousuke Masutani Shigeaki Mukoubara Hisatomi Arima |
| author_facet |
Toshiki Maeda Soichiro Yokota Takumi Nishi Shunsuke Funakoshi Masayoshi Tsuji Atsushi Satoh Makiko Abe Miki Kawazoe Chikara Yoshimura Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Toshitaka Yamanokuchi Kazuyo Iwanaga Akiko Morinaga Kaori Maki Tamami Ueno Kousuke Masutani Shigeaki Mukoubara Hisatomi Arima |
| author_sort |
Toshiki Maeda |
| title |
Association between pulse pressure and progression of chronic kidney disease |
| title_short |
Association between pulse pressure and progression of chronic kidney disease |
| title_full |
Association between pulse pressure and progression of chronic kidney disease |
| title_fullStr |
Association between pulse pressure and progression of chronic kidney disease |
| title_full_unstemmed |
Association between pulse pressure and progression of chronic kidney disease |
| title_sort |
association between pulse pressure and progression of chronic kidney disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bde9b4a1042b4e08910f25a9c24c3346 |
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