Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters

Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) seeds are edible crop classified as Traditional Chinese Medicine (TCM). Adlay bran (AB) is one of the wastes generated during adlay refining processes. In this work, supercritical fluid extract of AB (AB-SCF) was investigated to reveal its l...

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Autores principales:	Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai, Fang-Rong Chang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adlay bran supercritical fluid extract hypolipidemic capacity unsaturated fatty acids (UFAs) ferulate phytostanol esters Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/bdeb5a20ec7c4240877bbc63691def24
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spelling	oai:doaj.org-article:bdeb5a20ec7c4240877bbc63691def242021-11-17T06:22:29ZLipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters1663-981210.3389/fphar.2021.785944https://doaj.org/article/bdeb5a20ec7c4240877bbc63691def242021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.785944/fullhttps://doaj.org/toc/1663-9812Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) seeds are edible crop classified as Traditional Chinese Medicine (TCM). Adlay bran (AB) is one of the wastes generated during adlay refining processes. In this work, supercritical fluid extract of AB (AB-SCF) was investigated to reveal its lipid regulating potential and decode its bifunctional ingredients. AB-SCF×0.5 (30.84 mg/kg/body weight), AB-SCF×1 (61.67 mg/kg/BW), AB-SCF×5 (308.35 mg/kg/BW) and AB-SCF×10 (616.70 mg/kg/BW) were administrated to high fat-diet (HFD) induced hyperglycemic hamsters for 8 weeks. The results indicates that AB-SCF displays a prevention of dramatic body weight gains, lower levels of serum TG, TC, LDL-C and higher in HDL-C, amelioration of cardiovascular risk, alleviation of hepatic TG, TC and lipid peroxidation, and enhancement on cholesterol metabolism with higher bile acid excretion. Investigations on energy metabolic mechanism demonstrates that the hyperlipidemia mitigating capacities of AB-SCF are up-regulated on lipoprotein lipase, AMPK, p-AMPK and down-regulated at fatty acid synthase. Major bio-functional lipid compositions are identified as linoleic acid (28.59%) and oleic acid (56.95%). Non-lipid chemical and active markers are confirmed as 3-O-(trans-4-feruloyl)-β-sitostanol (1463.42 ppm), 3-O-(cis-4-feruloyl)-β-sitostanol (162.60 ppm), and β-sitosterol (4117.72 ppm). These compositions might synergistically responsible for the mentioned activities and can be regarded as analytical targets in quality control. AB-SCF may be considered as a promising complementary supplement, and developed as a functional food or new botanical drug in the future.Chiao-Chih HuangTzu-Ching LinChiung-Hui LiuHao-Chun HuSzu-Yin YuShu-Jing WuMing-Hong YenYi-Hong TsaiYi-Hong TsaiFang-Rong ChangFang-Rong ChangFang-Rong ChangFang-Rong ChangFrontiers Media S.A.articleadlay bransupercritical fluid extracthypolipidemic capacityunsaturated fatty acids (UFAs)ferulate phytostanol estersTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adlay bran supercritical fluid extract hypolipidemic capacity unsaturated fatty acids (UFAs) ferulate phytostanol esters Therapeutics. Pharmacology RM1-950
spellingShingle	adlay bran supercritical fluid extract hypolipidemic capacity unsaturated fatty acids (UFAs) ferulate phytostanol esters Therapeutics. Pharmacology RM1-950 Chiao-Chih Huang Tzu-Ching Lin Chiung-Hui Liu Hao-Chun Hu Szu-Yin Yu Shu-Jing Wu Ming-Hong Yen Yi-Hong Tsai Yi-Hong Tsai Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
description	Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) seeds are edible crop classified as Traditional Chinese Medicine (TCM). Adlay bran (AB) is one of the wastes generated during adlay refining processes. In this work, supercritical fluid extract of AB (AB-SCF) was investigated to reveal its lipid regulating potential and decode its bifunctional ingredients. AB-SCF×0.5 (30.84 mg/kg/body weight), AB-SCF×1 (61.67 mg/kg/BW), AB-SCF×5 (308.35 mg/kg/BW) and AB-SCF×10 (616.70 mg/kg/BW) were administrated to high fat-diet (HFD) induced hyperglycemic hamsters for 8 weeks. The results indicates that AB-SCF displays a prevention of dramatic body weight gains, lower levels of serum TG, TC, LDL-C and higher in HDL-C, amelioration of cardiovascular risk, alleviation of hepatic TG, TC and lipid peroxidation, and enhancement on cholesterol metabolism with higher bile acid excretion. Investigations on energy metabolic mechanism demonstrates that the hyperlipidemia mitigating capacities of AB-SCF are up-regulated on lipoprotein lipase, AMPK, p-AMPK and down-regulated at fatty acid synthase. Major bio-functional lipid compositions are identified as linoleic acid (28.59%) and oleic acid (56.95%). Non-lipid chemical and active markers are confirmed as 3-O-(trans-4-feruloyl)-β-sitostanol (1463.42 ppm), 3-O-(cis-4-feruloyl)-β-sitostanol (162.60 ppm), and β-sitosterol (4117.72 ppm). These compositions might synergistically responsible for the mentioned activities and can be regarded as analytical targets in quality control. AB-SCF may be considered as a promising complementary supplement, and developed as a functional food or new botanical drug in the future.
format	article
author	Chiao-Chih Huang Tzu-Ching Lin Chiung-Hui Liu Hao-Chun Hu Szu-Yin Yu Shu-Jing Wu Ming-Hong Yen Yi-Hong Tsai Yi-Hong Tsai Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang
author_facet	Chiao-Chih Huang Tzu-Ching Lin Chiung-Hui Liu Hao-Chun Hu Szu-Yin Yu Shu-Jing Wu Ming-Hong Yen Yi-Hong Tsai Yi-Hong Tsai Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang Fang-Rong Chang
author_sort	Chiao-Chih Huang
title	Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
title_short	Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
title_full	Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
title_fullStr	Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
title_full_unstemmed	Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
title_sort	lipid metabolism and its mechanism triggered by supercritical co2 extract of adlay (coix lacryma-jobi var. ma-yuen (rom. caill.) stapf) bran in high-fat diet induced hyperlipidemic hamsters
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bdeb5a20ec7c4240877bbc63691def24
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Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters

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