A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.

Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hy...

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Autores principales: Africa Millán-Uclés, Blanca Díaz-Castro, Paula García-Flores, Alicia Báez, José Antonio Pérez-Simón, José López-Barneo, José I Piruat
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/bdebaca2f681426d9c2df54d9c73c9b3
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