A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hy...
Guardado en:
Autores principales: | Africa Millán-Uclés, Blanca Díaz-Castro, Paula García-Flores, Alicia Báez, José Antonio Pérez-Simón, José López-Barneo, José I Piruat |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/bdebaca2f681426d9c2df54d9c73c9b3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
por: Atsushi Okuma, et al.
Publicado: (2017) -
Cáncer gástrico y regulación del crecimiento tumoral.: Estudio de marcadores de proliferación celular y del complejo proteínas p53/p21WAF1/CIP1/mdm-2
por: Villaseca H,Miguel, et al.
Publicado: (2000) -
CIP and potato improvement in the Caribbean
por: Sawyer, Richard L.
Publicado: (2014) -
EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.
por: Anna Rommer, et al.
Publicado: (2013) -
Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4
por: Ya-Lan Chang, et al.
Publicado: (2017)