Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma

ObjectiveTo compare the dosimetric parameters of different radiotherapy plans [helical tomotherapy (HT), volume-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiation therapy (FF-IMRT)] for locally advanced nasopharyngeal carcinoma (NPC).MethodsA total of 15 patients with locall...

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Autores principales:	Shan Lu, Huiqi Fan, Xueyuan Hu, Xin Li, Yingying Kuang, Deyang Yu, Shanshan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiotherapy technique helical tomotherapy (HT) volume-modulated arc therapy (VMAT) fixed-field intensity-modulated radiation therapy (FF-IMRT) nasopharyngeal carcinoma (NPC) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bdec0eb6b1fd46feb9b3c326678c64c1
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spelling	oai:doaj.org-article:bdec0eb6b1fd46feb9b3c326678c64c12021-11-05T09:21:20ZDosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma2234-943X10.3389/fonc.2021.764946https://doaj.org/article/bdec0eb6b1fd46feb9b3c326678c64c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.764946/fullhttps://doaj.org/toc/2234-943XObjectiveTo compare the dosimetric parameters of different radiotherapy plans [helical tomotherapy (HT), volume-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiation therapy (FF-IMRT)] for locally advanced nasopharyngeal carcinoma (NPC).MethodsA total of 15 patients with locally advanced NPC were chosen for this retrospective analysis and replanned for HT, VMAT, and FF-IMRT. The prescribed planning target volume (PTV) dose for the primary tumor and metastatic lymph nodes was 70 Gy (2.12 Gy/fraction, delivered over 33 fractions). The prescribed PTV dose for the high-risk subclinical region was 59.4 Gy (1.8 Gy/fraction, delivered over 33 fractions). The dosimetric parameters of the PTV and organs at risk (OARs) and the efficiency of radiation delivery were assessed and compared using the paired-samples t-test.ResultsCompared with VMAT and FF-IMRT plans, HT plans significantly improved the mean conformity index (CI) and homogeneity index (HI). The HT plans reduced the maximum doses delivered to OARs, such as the brainstem, spinal cord, and optic nerves, and significantly reduced the volume delivered to the high-dose region, especially when examining the V30 value of the parotid glands. However, VMAT reduced the treatment time and improved the efficiency of radiation delivery compared with HT.ConclusionsFor locally advanced NPC, the results showed that HT and VMAT possessed better target homogeneity and conformity, reducing the dose delivered to OARs compared with conventional FF-IMRT, with HT achieving the best effect. Among the techniques studied, VMAT had the shortest radiation delivery time. The results of this study can provide guidance for the selection of appropriate radiation technologies used to treat patients with locally advanced NPC who are undergoing concurrent chemoradiotherapy.Shan LuHuiqi FanXueyuan HuXin LiYingying KuangDeyang YuShanshan YangFrontiers Media S.A.articleradiotherapy techniquehelical tomotherapy (HT)volume-modulated arc therapy (VMAT)fixed-field intensity-modulated radiation therapy (FF-IMRT)nasopharyngeal carcinoma (NPC)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiotherapy technique helical tomotherapy (HT) volume-modulated arc therapy (VMAT) fixed-field intensity-modulated radiation therapy (FF-IMRT) nasopharyngeal carcinoma (NPC) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiotherapy technique helical tomotherapy (HT) volume-modulated arc therapy (VMAT) fixed-field intensity-modulated radiation therapy (FF-IMRT) nasopharyngeal carcinoma (NPC) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shan Lu Huiqi Fan Xueyuan Hu Xin Li Yingying Kuang Deyang Yu Shanshan Yang Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
description	ObjectiveTo compare the dosimetric parameters of different radiotherapy plans [helical tomotherapy (HT), volume-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiation therapy (FF-IMRT)] for locally advanced nasopharyngeal carcinoma (NPC).MethodsA total of 15 patients with locally advanced NPC were chosen for this retrospective analysis and replanned for HT, VMAT, and FF-IMRT. The prescribed planning target volume (PTV) dose for the primary tumor and metastatic lymph nodes was 70 Gy (2.12 Gy/fraction, delivered over 33 fractions). The prescribed PTV dose for the high-risk subclinical region was 59.4 Gy (1.8 Gy/fraction, delivered over 33 fractions). The dosimetric parameters of the PTV and organs at risk (OARs) and the efficiency of radiation delivery were assessed and compared using the paired-samples t-test.ResultsCompared with VMAT and FF-IMRT plans, HT plans significantly improved the mean conformity index (CI) and homogeneity index (HI). The HT plans reduced the maximum doses delivered to OARs, such as the brainstem, spinal cord, and optic nerves, and significantly reduced the volume delivered to the high-dose region, especially when examining the V30 value of the parotid glands. However, VMAT reduced the treatment time and improved the efficiency of radiation delivery compared with HT.ConclusionsFor locally advanced NPC, the results showed that HT and VMAT possessed better target homogeneity and conformity, reducing the dose delivered to OARs compared with conventional FF-IMRT, with HT achieving the best effect. Among the techniques studied, VMAT had the shortest radiation delivery time. The results of this study can provide guidance for the selection of appropriate radiation technologies used to treat patients with locally advanced NPC who are undergoing concurrent chemoradiotherapy.
format	article
author	Shan Lu Huiqi Fan Xueyuan Hu Xin Li Yingying Kuang Deyang Yu Shanshan Yang
author_facet	Shan Lu Huiqi Fan Xueyuan Hu Xin Li Yingying Kuang Deyang Yu Shanshan Yang
author_sort	Shan Lu
title	Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
title_short	Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
title_full	Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
title_fullStr	Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
title_full_unstemmed	Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma
title_sort	dosimetric comparison of helical tomotherapy, volume-modulated arc therapy, and fixed-field intensity-modulated radiation therapy in locally advanced nasopharyngeal carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bdec0eb6b1fd46feb9b3c326678c64c1
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Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma

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