Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.

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Autores principales:	Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis, Michela Perego, Clemens Krepler, Xiaowei Xu, Christine Wagner, Denitsa Hristova, Jie Zhang, Tian Tian, Zhi Wei, Qin Liu, Kanika Garg, Johannes Griss, Rufus Hards, Margarita Maurer, Christine Hafner, Marius Mayerhöfer, Georgios Karanikas, Ahmad Jalili, Verena Bauer-Pohl, Felix Weihsengruber, Klemens Rappersberger, Josef Koller, Roland Lang, Courtney Hudgens, Guo Chen, Michael Tetzlaff, Lawrence Wu, Dennie Tompers Frederick, Richard A. Scolyer, Georgina V. Long, Manashree Damle, Courtney Ellingsworth, Leon Grinman, Harry Choi, Brian J. Gavin, Margaret Dunagin, Arjun Raj, Nathalie Scholler, Laura Gross, Marilda Beqiri, Keiryn Bennett, Ian Watson, Helmut Schaider, Michael A. Davies, Jennifer Wargo, Brian J. Czerniecki, Lynn Schuchter, Dorothee Herlyn, Keith Flaherty, Meenhard Herlyn, Stephan N. Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdec5a8059084d31b97839ef9a5cc86d
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spelling	oai:doaj.org-article:bdec5a8059084d31b97839ef9a5cc86d2021-12-02T15:39:04ZTumor-associated B-cells induce tumor heterogeneity and therapy resistance10.1038/s41467-017-00452-42041-1723https://doaj.org/article/bdec5a8059084d31b97839ef9a5cc86d2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00452-4https://doaj.org/toc/2041-1723Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.Rajasekharan SomasundaramGao ZhangMizuho Fukunaga-KalabisMichela PeregoClemens KreplerXiaowei XuChristine WagnerDenitsa HristovaJie ZhangTian TianZhi WeiQin LiuKanika GargJohannes GrissRufus HardsMargarita MaurerChristine HafnerMarius MayerhöferGeorgios KaranikasAhmad JaliliVerena Bauer-PohlFelix WeihsengruberKlemens RappersbergerJosef KollerRoland LangCourtney HudgensGuo ChenMichael TetzlaffLawrence WuDennie Tompers FrederickRichard A. ScolyerGeorgina V. LongManashree DamleCourtney EllingsworthLeon GrinmanHarry ChoiBrian J. GavinMargaret DunaginArjun RajNathalie SchollerLaura GrossMarilda BeqiriKeiryn BennettIan WatsonHelmut SchaiderMichael A. DaviesJennifer WargoBrian J. CzernieckiLynn SchuchterDorothee HerlynKeith FlahertyMeenhard HerlynStephan N. WagnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajasekharan Somasundaram Gao Zhang Mizuho Fukunaga-Kalabis Michela Perego Clemens Krepler Xiaowei Xu Christine Wagner Denitsa Hristova Jie Zhang Tian Tian Zhi Wei Qin Liu Kanika Garg Johannes Griss Rufus Hards Margarita Maurer Christine Hafner Marius Mayerhöfer Georgios Karanikas Ahmad Jalili Verena Bauer-Pohl Felix Weihsengruber Klemens Rappersberger Josef Koller Roland Lang Courtney Hudgens Guo Chen Michael Tetzlaff Lawrence Wu Dennie Tompers Frederick Richard A. Scolyer Georgina V. Long Manashree Damle Courtney Ellingsworth Leon Grinman Harry Choi Brian J. Gavin Margaret Dunagin Arjun Raj Nathalie Scholler Laura Gross Marilda Beqiri Keiryn Bennett Ian Watson Helmut Schaider Michael A. Davies Jennifer Wargo Brian J. Czerniecki Lynn Schuchter Dorothee Herlyn Keith Flaherty Meenhard Herlyn Stephan N. Wagner Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
description	Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.
format	article
author	Rajasekharan Somasundaram Gao Zhang Mizuho Fukunaga-Kalabis Michela Perego Clemens Krepler Xiaowei Xu Christine Wagner Denitsa Hristova Jie Zhang Tian Tian Zhi Wei Qin Liu Kanika Garg Johannes Griss Rufus Hards Margarita Maurer Christine Hafner Marius Mayerhöfer Georgios Karanikas Ahmad Jalili Verena Bauer-Pohl Felix Weihsengruber Klemens Rappersberger Josef Koller Roland Lang Courtney Hudgens Guo Chen Michael Tetzlaff Lawrence Wu Dennie Tompers Frederick Richard A. Scolyer Georgina V. Long Manashree Damle Courtney Ellingsworth Leon Grinman Harry Choi Brian J. Gavin Margaret Dunagin Arjun Raj Nathalie Scholler Laura Gross Marilda Beqiri Keiryn Bennett Ian Watson Helmut Schaider Michael A. Davies Jennifer Wargo Brian J. Czerniecki Lynn Schuchter Dorothee Herlyn Keith Flaherty Meenhard Herlyn Stephan N. Wagner
author_facet	Rajasekharan Somasundaram Gao Zhang Mizuho Fukunaga-Kalabis Michela Perego Clemens Krepler Xiaowei Xu Christine Wagner Denitsa Hristova Jie Zhang Tian Tian Zhi Wei Qin Liu Kanika Garg Johannes Griss Rufus Hards Margarita Maurer Christine Hafner Marius Mayerhöfer Georgios Karanikas Ahmad Jalili Verena Bauer-Pohl Felix Weihsengruber Klemens Rappersberger Josef Koller Roland Lang Courtney Hudgens Guo Chen Michael Tetzlaff Lawrence Wu Dennie Tompers Frederick Richard A. Scolyer Georgina V. Long Manashree Damle Courtney Ellingsworth Leon Grinman Harry Choi Brian J. Gavin Margaret Dunagin Arjun Raj Nathalie Scholler Laura Gross Marilda Beqiri Keiryn Bennett Ian Watson Helmut Schaider Michael A. Davies Jennifer Wargo Brian J. Czerniecki Lynn Schuchter Dorothee Herlyn Keith Flaherty Meenhard Herlyn Stephan N. Wagner
author_sort	Rajasekharan Somasundaram
title	Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
title_short	Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
title_full	Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
title_fullStr	Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
title_full_unstemmed	Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
title_sort	tumor-associated b-cells induce tumor heterogeneity and therapy resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bdec5a8059084d31b97839ef9a5cc86d
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Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

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