Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.

Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivi...

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Autores principales:	Peter L Oliver, Mattéa J Finelli, Benjamin Edwards, Emmanuelle Bitoun, Darcy L Butts, Esther B E Becker, Michael T Cheeseman, Ben Davies, Kay E Davies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/bded789a20a14f05bd7a0ff17016ec81
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spelling	oai:doaj.org-article:bded789a20a14f05bd7a0ff17016ec812021-11-18T06:19:16ZOxr1 is essential for protection against oxidative stress-induced neurodegeneration.1553-73901553-740410.1371/journal.pgen.1002338https://doaj.org/article/bded789a20a14f05bd7a0ff17016ec812011-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028674/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. A conserved short isoform of Oxr1 is also sufficient to confer this neuroprotective property both in vitro and in vivo. In addition, biochemical assays indicate that Oxr1 itself is susceptible to cysteine-mediated oxidation. Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease.Peter L OliverMattéa J FinelliBenjamin EdwardsEmmanuelle BitounDarcy L ButtsEsther B E BeckerMichael T CheesemanBen DaviesKay E DaviesPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 7, Iss 10, p e1002338 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Peter L Oliver Mattéa J Finelli Benjamin Edwards Emmanuelle Bitoun Darcy L Butts Esther B E Becker Michael T Cheeseman Ben Davies Kay E Davies Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
description	Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. A conserved short isoform of Oxr1 is also sufficient to confer this neuroprotective property both in vitro and in vivo. In addition, biochemical assays indicate that Oxr1 itself is susceptible to cysteine-mediated oxidation. Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease.
format	article
author	Peter L Oliver Mattéa J Finelli Benjamin Edwards Emmanuelle Bitoun Darcy L Butts Esther B E Becker Michael T Cheeseman Ben Davies Kay E Davies
author_facet	Peter L Oliver Mattéa J Finelli Benjamin Edwards Emmanuelle Bitoun Darcy L Butts Esther B E Becker Michael T Cheeseman Ben Davies Kay E Davies
author_sort	Peter L Oliver
title	Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
title_short	Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
title_full	Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
title_fullStr	Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
title_full_unstemmed	Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
title_sort	oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/bded789a20a14f05bd7a0ff17016ec81
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Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.

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