Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study

Voltage-dependent calcium channel subunit alpha-2/delta-1 (α2δ1) has been identified as a marker of cancer stem cells in multiple malignant tumor types. However, α2δ1’s role in the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) was not reported. In our study, ten pairs of HSCC and peritu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu Qiang, Dong Yanbo, Yuan Shuoqing, Yu Minghang, Liu Liangfa, Zhang Qing
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	hypopharyngeal carcinoma α2δ1 immunohistochemistry survival analysis prognosis Medicine R
Acceso en línea:	https://doaj.org/article/bdf0e5be77ef446786479c69f1b1c5ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bdf0e5be77ef446786479c69f1b1c5ca
record_format	dspace
spelling	oai:doaj.org-article:bdf0e5be77ef446786479c69f1b1c5ca2021-12-05T14:10:55ZPrognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study2391-546310.1515/med-2021-0356https://doaj.org/article/bdf0e5be77ef446786479c69f1b1c5ca2021-09-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0356https://doaj.org/toc/2391-5463Voltage-dependent calcium channel subunit alpha-2/delta-1 (α2δ1) has been identified as a marker of cancer stem cells in multiple malignant tumor types. However, α2δ1’s role in the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) was not reported. In our study, ten pairs of HSCC and peritumoral normal tissues were used for immunohistochemistry assessment. And α2δ1 expression levels of 34 more HSCC samples were also evaluated, represented by the integral optic density using Image-Pro Plus. Clinicopathological associations and prognostic value of α2δ1 were analyzed. As a result, α2δ1 expression was frequently increased in HSCC tissues. Although the correlation between patients’ clinicopathological characteristics and their α2δ1 expression levels was not significant, α2δ1 expression was significantly correlated with unfavorable overall survival (OS) (P = 0.018) and progression-free survival (PFS) (P = 0.023). Univariate and multivariate cox regression analyses suggested α2δ1’s prognostic role for both OS and PFS (P = 0.013 and 0.011, respectively). This study specifically demonstrated that α2δ1 regularly increased in HSCC compared with peritumoral tissues, and α2δ1 could act as a promising prognostic marker in HSCC patients.Liu QiangDong YanboYuan ShuoqingYu MinghangLiu LiangfaZhang QingDe Gruyterarticlehypopharyngeal carcinomaα2δ1immunohistochemistrysurvival analysisprognosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1395-1402 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypopharyngeal carcinoma α2δ1 immunohistochemistry survival analysis prognosis Medicine R
spellingShingle	hypopharyngeal carcinoma α2δ1 immunohistochemistry survival analysis prognosis Medicine R Liu Qiang Dong Yanbo Yuan Shuoqing Yu Minghang Liu Liangfa Zhang Qing Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
description	Voltage-dependent calcium channel subunit alpha-2/delta-1 (α2δ1) has been identified as a marker of cancer stem cells in multiple malignant tumor types. However, α2δ1’s role in the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) was not reported. In our study, ten pairs of HSCC and peritumoral normal tissues were used for immunohistochemistry assessment. And α2δ1 expression levels of 34 more HSCC samples were also evaluated, represented by the integral optic density using Image-Pro Plus. Clinicopathological associations and prognostic value of α2δ1 were analyzed. As a result, α2δ1 expression was frequently increased in HSCC tissues. Although the correlation between patients’ clinicopathological characteristics and their α2δ1 expression levels was not significant, α2δ1 expression was significantly correlated with unfavorable overall survival (OS) (P = 0.018) and progression-free survival (PFS) (P = 0.023). Univariate and multivariate cox regression analyses suggested α2δ1’s prognostic role for both OS and PFS (P = 0.013 and 0.011, respectively). This study specifically demonstrated that α2δ1 regularly increased in HSCC compared with peritumoral tissues, and α2δ1 could act as a promising prognostic marker in HSCC patients.
format	article
author	Liu Qiang Dong Yanbo Yuan Shuoqing Yu Minghang Liu Liangfa Zhang Qing
author_facet	Liu Qiang Dong Yanbo Yuan Shuoqing Yu Minghang Liu Liangfa Zhang Qing
author_sort	Liu Qiang
title	Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
title_short	Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
title_full	Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
title_fullStr	Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
title_full_unstemmed	Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study
title_sort	prognostic value of α2δ1 in hypopharyngeal carcinoma: a retrospective study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/bdf0e5be77ef446786479c69f1b1c5ca
work_keys_str_mv	AT liuqiang prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy AT dongyanbo prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy AT yuanshuoqing prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy AT yuminghang prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy AT liuliangfa prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy AT zhangqing prognosticvalueofa2d1inhypopharyngealcarcinomaaretrospectivestudy
_version_	1718371625846439936

Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study

Ejemplares similares