Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants

The advances in acute phase care have firmly established the practice of organ transplantation in the last several decades. Then, the next issues that loom large in the field of transplantation include antibody-mediated rejection (ABMR) and recurrent primary disease. Acute ABMR is a daunting hurdle...

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Auteurs principaux:	Tsukasa Nakamura, Takayuki Shirouzu
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	antibody-mediated rejection recurrent primary disease renal transplantation liver transplantation pancreas transplantation Medicine R
Accès en ligne:	https://doaj.org/article/bdf1260837724ba386e10f95076f6b82
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spelling	oai:doaj.org-article:bdf1260837724ba386e10f95076f6b822021-11-25T18:02:36ZAntibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants10.3390/jcm102254172077-0383https://doaj.org/article/bdf1260837724ba386e10f95076f6b822021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5417https://doaj.org/toc/2077-0383The advances in acute phase care have firmly established the practice of organ transplantation in the last several decades. Then, the next issues that loom large in the field of transplantation include antibody-mediated rejection (ABMR) and recurrent primary disease. Acute ABMR is a daunting hurdle in the performance of organ transplantation. The recent progress in desensitization and preoperative monitoring of donor-specific antibodies enables us to increase positive outcomes. However, chronic active ABMR is one of the most significant problems we currently face. On the other hand, recurrent primary disease is problematic for many recipients. Notably, some recipients, unfortunately, lost their vital organs due to this recurrence. Although some progress has been achieved in these two areas, many other factors remain largely obscure. In this review, these two topics will be discussed in light of recent discoveries.Tsukasa NakamuraTakayuki ShirouzuMDPI AGarticleantibody-mediated rejectionrecurrent primary diseaserenal transplantationliver transplantationpancreas transplantationMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5417, p 5417 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibody-mediated rejection recurrent primary disease renal transplantation liver transplantation pancreas transplantation Medicine R
spellingShingle	antibody-mediated rejection recurrent primary disease renal transplantation liver transplantation pancreas transplantation Medicine R Tsukasa Nakamura Takayuki Shirouzu Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
description	The advances in acute phase care have firmly established the practice of organ transplantation in the last several decades. Then, the next issues that loom large in the field of transplantation include antibody-mediated rejection (ABMR) and recurrent primary disease. Acute ABMR is a daunting hurdle in the performance of organ transplantation. The recent progress in desensitization and preoperative monitoring of donor-specific antibodies enables us to increase positive outcomes. However, chronic active ABMR is one of the most significant problems we currently face. On the other hand, recurrent primary disease is problematic for many recipients. Notably, some recipients, unfortunately, lost their vital organs due to this recurrence. Although some progress has been achieved in these two areas, many other factors remain largely obscure. In this review, these two topics will be discussed in light of recent discoveries.
format	article
author	Tsukasa Nakamura Takayuki Shirouzu
author_facet	Tsukasa Nakamura Takayuki Shirouzu
author_sort	Tsukasa Nakamura
title	Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
title_short	Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
title_full	Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
title_fullStr	Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
title_full_unstemmed	Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
title_sort	antibody-mediated rejection and recurrent primary disease: two main obstacles in abdominal kidney, liver, and pancreas transplants
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bdf1260837724ba386e10f95076f6b82
work_keys_str_mv	AT tsukasanakamura antibodymediatedrejectionandrecurrentprimarydiseasetwomainobstaclesinabdominalkidneyliverandpancreastransplants AT takayukishirouzu antibodymediatedrejectionandrecurrentprimarydiseasetwomainobstaclesinabdominalkidneyliverandpancreastransplants
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Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants

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