Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers. They find that loss of p53 enhances progression in both models but only influences initiation in the pancreas.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mandar Deepak Muzumdar, Kimberly Judith Dorans, Katherine Minjee Chung, Rebecca Robbins, Tuomas Tammela, Vasilena Gocheva, Carman Man-Chung Li, Tyler Jacks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdfbd4f291674e74b291c197db3849ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bdfbd4f291674e74b291c197db3849ac
record_format	dspace
spelling	oai:doaj.org-article:bdfbd4f291674e74b291c197db3849ac2021-12-02T14:39:31ZClonal dynamics following p53 loss of heterozygosity in Kras-driven cancers10.1038/ncomms126852041-1723https://doaj.org/article/bdfbd4f291674e74b291c197db3849ac2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12685https://doaj.org/toc/2041-1723Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers. They find that loss of p53 enhances progression in both models but only influences initiation in the pancreas.Mandar Deepak MuzumdarKimberly Judith DoransKatherine Minjee ChungRebecca RobbinsTuomas TammelaVasilena GochevaCarman Man-Chung LiTyler JacksNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mandar Deepak Muzumdar Kimberly Judith Dorans Katherine Minjee Chung Rebecca Robbins Tuomas Tammela Vasilena Gocheva Carman Man-Chung Li Tyler Jacks Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
description	Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers. They find that loss of p53 enhances progression in both models but only influences initiation in the pancreas.
format	article
author	Mandar Deepak Muzumdar Kimberly Judith Dorans Katherine Minjee Chung Rebecca Robbins Tuomas Tammela Vasilena Gocheva Carman Man-Chung Li Tyler Jacks
author_facet	Mandar Deepak Muzumdar Kimberly Judith Dorans Katherine Minjee Chung Rebecca Robbins Tuomas Tammela Vasilena Gocheva Carman Man-Chung Li Tyler Jacks
author_sort	Mandar Deepak Muzumdar
title	Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
title_short	Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
title_full	Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
title_fullStr	Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
title_full_unstemmed	Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
title_sort	clonal dynamics following p53 loss of heterozygosity in kras-driven cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bdfbd4f291674e74b291c197db3849ac
work_keys_str_mv	AT mandardeepakmuzumdar clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT kimberlyjudithdorans clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT katherineminjeechung clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT rebeccarobbins clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT tuomastammela clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT vasilenagocheva clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT carmanmanchungli clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers AT tylerjacks clonaldynamicsfollowingp53lossofheterozygosityinkrasdrivencancers
_version_	1718390615071260672

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Ejemplares similares