L-Lysine α-Oxidase: Enzyme with Anticancer Properties

L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO...

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Autores principales:	Elena V. Lukasheva, Gulalek Babayeva, Saida Sh. Karshieva, Dmitry D. Zhdanov, Vadim S. Pokrovsky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anticancer enzymes tumor therapy L-amino acid oxidase L-lysine α-oxidase L-lysine colon cancer treatment Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/bdfdb068d6764ddab93558ebef56e2ac
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spelling	oai:doaj.org-article:bdfdb068d6764ddab93558ebef56e2ac2021-11-25T18:39:05ZL-Lysine α-Oxidase: Enzyme with Anticancer Properties10.3390/ph141110701424-8247https://doaj.org/article/bdfdb068d6764ddab93558ebef56e2ac2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1070https://doaj.org/toc/1424-8247L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H<sub>2</sub>O<sub>2</sub>, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.Elena V. LukashevaGulalek BabayevaSaida Sh. KarshievaDmitry D. ZhdanovVadim S. PokrovskyMDPI AGarticleanticancer enzymestumor therapyL-amino acid oxidaseL-lysine α-oxidaseL-lysinecolon cancer treatmentMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1070, p 1070 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer enzymes tumor therapy L-amino acid oxidase L-lysine α-oxidase L-lysine colon cancer treatment Medicine R Pharmacy and materia medica RS1-441
spellingShingle	anticancer enzymes tumor therapy L-amino acid oxidase L-lysine α-oxidase L-lysine colon cancer treatment Medicine R Pharmacy and materia medica RS1-441 Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky L-Lysine α-Oxidase: Enzyme with Anticancer Properties
description	L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H<sub>2</sub>O<sub>2</sub>, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.
format	article
author	Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky
author_facet	Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky
author_sort	Elena V. Lukasheva
title	L-Lysine α-Oxidase: Enzyme with Anticancer Properties
title_short	L-Lysine α-Oxidase: Enzyme with Anticancer Properties
title_full	L-Lysine α-Oxidase: Enzyme with Anticancer Properties
title_fullStr	L-Lysine α-Oxidase: Enzyme with Anticancer Properties
title_full_unstemmed	L-Lysine α-Oxidase: Enzyme with Anticancer Properties
title_sort	l-lysine α-oxidase: enzyme with anticancer properties
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bdfdb068d6764ddab93558ebef56e2ac
work_keys_str_mv	AT elenavlukasheva llysineaoxidaseenzymewithanticancerproperties AT gulalekbabayeva llysineaoxidaseenzymewithanticancerproperties AT saidashkarshieva llysineaoxidaseenzymewithanticancerproperties AT dmitrydzhdanov llysineaoxidaseenzymewithanticancerproperties AT vadimspokrovsky llysineaoxidaseenzymewithanticancerproperties
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L-Lysine α-Oxidase: Enzyme with Anticancer Properties

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