Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study

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Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study

Background: Cognitive disorders associated with schizophrenia are closely linked to prefrontal cortex (PFC) dysfunction. Administration of the non-competitive NMDA receptor antagonist ketamine (KET) induces cognitive impairment in animals, producing effects similar to those observed in schizophrenic...

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Auteurs principaux:	Agata Korlatowicz, Maciej Kuśmider, Marta Szlachta, Paulina Pabian, Joanna Solich, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	ketamine clozapine GPCRs βarrestins ERK1/2 Girk3 Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/bdffb22fddcf4d70b777e83dfe97f5e5
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