Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment

Shuihong Li,1,* Xiaodan Wei,2,* Sisi Li,1 Cuiming Zhu,1 Chunhui Wu2 1Institution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of China; 2School of Life Science and Technology, University of Electronic Science and Tech...

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Autores principales: Li S, Wei X, Zhu C, Wu C
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Lenguaje:EN
Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:be01a91c9d71485b9eaa1ef1b45160322021-12-02T12:26:40ZUp-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment1178-2013https://doaj.org/article/be01a91c9d71485b9eaa1ef1b45160322020-11-01T00:00:00Zhttps://www.dovepress.com/up-conversion-luminescent-nanoparticles-for-molecular-imaging-cancer-d-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shuihong Li,1,* Xiaodan Wei,2,* Sisi Li,1 Cuiming Zhu,1 Chunhui Wu2 1Institution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of China; 2School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuihong LiInstitution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of ChinaTel/Fax +86 734 8282907Email zhoubaoxi520@163.comChunhui WuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, People’s Republic of ChinaTel/Fax +86 28 83203353Email wuchunhui@uestc.edu.cnAbstract: In the past few years, we have witnessed great development and application potential of various up-conversion luminescent nanoparticles (UCNPs) in the nanomedicine field. Based on the unique luminescent mechanism of UCNPs and the distinguishable features of cancer biomarkers and the microenvironment, an increasing number of smart UCNPs nanoprobes have been designed and widely applied to molecular imaging, cancer diagnosis, and treatment. Considerable technological success has been achieved, but the main obstacles to oncology nanomedicine is becoming an incomplete understanding of nano–bio interactions, the challenges regarding chemistry manufacturing and controls required for clinical translation and so on. This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on our growing understanding of tumor biology and smart nano-devices for accelerating the commercialization of UCNPs.Keywords: multimodal imaging, cancer biomarkers, tumor microenvironmentLi SWei XLi SZhu CWu CDove Medical Pressarticlemultimodal imagingcancer biomarkerstumor microenvironmentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9431-9445 (2020)
institution DOAJ
collection DOAJ
language EN
topic multimodal imaging
cancer biomarkers
tumor microenvironment
Medicine (General)
R5-920
spellingShingle multimodal imaging
cancer biomarkers
tumor microenvironment
Medicine (General)
R5-920
Li S
Wei X
Li S
Zhu C
Wu C
Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
description Shuihong Li,1,* Xiaodan Wei,2,* Sisi Li,1 Cuiming Zhu,1 Chunhui Wu2 1Institution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of China; 2School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuihong LiInstitution of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of ChinaTel/Fax +86 734 8282907Email zhoubaoxi520@163.comChunhui WuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, People’s Republic of ChinaTel/Fax +86 28 83203353Email wuchunhui@uestc.edu.cnAbstract: In the past few years, we have witnessed great development and application potential of various up-conversion luminescent nanoparticles (UCNPs) in the nanomedicine field. Based on the unique luminescent mechanism of UCNPs and the distinguishable features of cancer biomarkers and the microenvironment, an increasing number of smart UCNPs nanoprobes have been designed and widely applied to molecular imaging, cancer diagnosis, and treatment. Considerable technological success has been achieved, but the main obstacles to oncology nanomedicine is becoming an incomplete understanding of nano–bio interactions, the challenges regarding chemistry manufacturing and controls required for clinical translation and so on. This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on our growing understanding of tumor biology and smart nano-devices for accelerating the commercialization of UCNPs.Keywords: multimodal imaging, cancer biomarkers, tumor microenvironment
format article
author Li S
Wei X
Li S
Zhu C
Wu C
author_facet Li S
Wei X
Li S
Zhu C
Wu C
author_sort Li S
title Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
title_short Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
title_full Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
title_fullStr Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
title_full_unstemmed Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
title_sort up-conversion luminescent nanoparticles for molecular imaging, cancer diagnosis and treatment
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/be01a91c9d71485b9eaa1ef1b4516032
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AT lis upconversionluminescentnanoparticlesformolecularimagingcancerdiagnosisandtreatment
AT zhuc upconversionluminescentnanoparticlesformolecularimagingcancerdiagnosisandtreatment
AT wuc upconversionluminescentnanoparticlesformolecularimagingcancerdiagnosisandtreatment
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