SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS

Thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of the antimicrobial drugs Triclosan and Triclocarban in five volatile organic solvents were calculated from solubility values at temperatures from 293.15 to 313.15 K. Triclosan and Triclocarban solubility was...

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Autores principales:	Daniel R. DELGADO, Andrés R. HOLGUÍN, Fleming MARTÍNEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2012
Materias:	Antimicrobial drugs Solubility Transfer Chemical thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/be03169f018749a48690be56d84f6a0d
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spelling	oai:doaj.org-article:be03169f018749a48690be56d84f6a0d2021-11-19T04:12:58ZSOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS0121-40042145-2660https://doaj.org/article/be03169f018749a48690be56d84f6a0d2012-04-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10838https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of the antimicrobial drugs Triclosan and Triclocarban in five volatile organic solvents were calculated from solubility values at temperatures from 293.15 to 313.15 K. Triclosan and Triclocarban solubility was determined in acetone, acetonitrile (AcCN), ethyl acetate (AcOEt), methanol (MetOH), and cyclohexane (CH). The excess of Gibbs energy and the activity coefficients of the solutes were also calculated. The Triclosan solubilities were greater than those of Triclocarban in all the solvents studied. At 298.15 K the solubility diminished for Triclosan in the order, acetone > AcOEt > AcCN > MetOH > CH, while it diminished for Triclocarban in the order, acetone > AcOEt > MetOH > AcCN > CH. On the other hand, thermodynamic quantities relative to the transfer process of these drugs from CH to all other organic solvents, as well as from water to organic solvents for Triclosan were also calculated in order to estimate the hydrogen-bonding contributions. Daniel R. DELGADOAndrés R. HOLGUÍNFleming MARTÍNEZUniversidad de AntioquiaarticleAntimicrobial drugsSolubilityTransferChemical thermodynamics.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 19, Iss 1 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimicrobial drugs Solubility Transfer Chemical thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Antimicrobial drugs Solubility Transfer Chemical thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Daniel R. DELGADO Andrés R. HOLGUÍN Fleming MARTÍNEZ SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
description	Thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of the antimicrobial drugs Triclosan and Triclocarban in five volatile organic solvents were calculated from solubility values at temperatures from 293.15 to 313.15 K. Triclosan and Triclocarban solubility was determined in acetone, acetonitrile (AcCN), ethyl acetate (AcOEt), methanol (MetOH), and cyclohexane (CH). The excess of Gibbs energy and the activity coefficients of the solutes were also calculated. The Triclosan solubilities were greater than those of Triclocarban in all the solvents studied. At 298.15 K the solubility diminished for Triclosan in the order, acetone > AcOEt > AcCN > MetOH > CH, while it diminished for Triclocarban in the order, acetone > AcOEt > MetOH > AcCN > CH. On the other hand, thermodynamic quantities relative to the transfer process of these drugs from CH to all other organic solvents, as well as from water to organic solvents for Triclosan were also calculated in order to estimate the hydrogen-bonding contributions.
format	article
author	Daniel R. DELGADO Andrés R. HOLGUÍN Fleming MARTÍNEZ
author_facet	Daniel R. DELGADO Andrés R. HOLGUÍN Fleming MARTÍNEZ
author_sort	Daniel R. DELGADO
title	SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
title_short	SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
title_full	SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
title_fullStr	SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
title_full_unstemmed	SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS
title_sort	solution thermodynamics of triclosan and triclocarban in some volatile organic solvents
publisher	Universidad de Antioquia
publishDate	2012
url	https://doaj.org/article/be03169f018749a48690be56d84f6a0d
work_keys_str_mv	AT danielrdelgado solutionthermodynamicsoftriclosanandtriclocarbaninsomevolatileorganicsolvents AT andresrholguin solutionthermodynamicsoftriclosanandtriclocarbaninsomevolatileorganicsolvents AT flemingmartinez solutionthermodynamicsoftriclosanandtriclocarbaninsomevolatileorganicsolvents
_version_	1718420517542690816

SOLUTION THERMODYNAMICS OF TRICLOSAN AND TRICLOCARBAN IN SOME VOLATILE ORGANIC SOLVENTS

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