Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes

Estimates of human mutation rates differ substantially based on the approach. Here, the authors present a multi-generational estimate from the autozygous segment in a non-European population that gives insight into the contribution of post-zygotic mutations and population-specific mutational process...

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Autores principales:	Vagheesh M. Narasimhan, Raheleh Rahbari, Aylwyn Scally, Arthur Wuster, Dan Mason, Yali Xue, John Wright, Richard C. Trembath, Eamonn R. Maher, David A. van Heel, Adam Auton, Matthew E. Hurles, Chris Tyler-Smith, Richard Durbin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be066eba4bc04f5e95c7ffd6d2e23463
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spelling	oai:doaj.org-article:be066eba4bc04f5e95c7ffd6d2e234632021-12-02T14:16:40ZEstimating the human mutation rate from autozygous segments reveals population differences in human mutational processes10.1038/s41467-017-00323-y2041-1723https://doaj.org/article/be066eba4bc04f5e95c7ffd6d2e234632017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00323-yhttps://doaj.org/toc/2041-1723Estimates of human mutation rates differ substantially based on the approach. Here, the authors present a multi-generational estimate from the autozygous segment in a non-European population that gives insight into the contribution of post-zygotic mutations and population-specific mutational processes.Vagheesh M. NarasimhanRaheleh RahbariAylwyn ScallyArthur WusterDan MasonYali XueJohn WrightRichard C. TrembathEamonn R. MaherDavid A. van HeelAdam AutonMatthew E. HurlesChris Tyler-SmithRichard DurbinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vagheesh M. Narasimhan Raheleh Rahbari Aylwyn Scally Arthur Wuster Dan Mason Yali Xue John Wright Richard C. Trembath Eamonn R. Maher David A. van Heel Adam Auton Matthew E. Hurles Chris Tyler-Smith Richard Durbin Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
description	Estimates of human mutation rates differ substantially based on the approach. Here, the authors present a multi-generational estimate from the autozygous segment in a non-European population that gives insight into the contribution of post-zygotic mutations and population-specific mutational processes.
format	article
author	Vagheesh M. Narasimhan Raheleh Rahbari Aylwyn Scally Arthur Wuster Dan Mason Yali Xue John Wright Richard C. Trembath Eamonn R. Maher David A. van Heel Adam Auton Matthew E. Hurles Chris Tyler-Smith Richard Durbin
author_facet	Vagheesh M. Narasimhan Raheleh Rahbari Aylwyn Scally Arthur Wuster Dan Mason Yali Xue John Wright Richard C. Trembath Eamonn R. Maher David A. van Heel Adam Auton Matthew E. Hurles Chris Tyler-Smith Richard Durbin
author_sort	Vagheesh M. Narasimhan
title	Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
title_short	Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
title_full	Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
title_fullStr	Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
title_full_unstemmed	Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
title_sort	estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/be066eba4bc04f5e95c7ffd6d2e23463
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes

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