Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.

<h4>Objectives</h4>To characterize the pattern of approved anti-vascular endothelial growth factor (VEGF) treatments among patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the United Arab Emirates (UAE).<h4>Method</h4>This...

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Autores principales:	Igor Kozak, Avinash Gurbaxani, Ammar Safar, Prasan Rao, Amal Masalmeh, Hazar Assaf, Mohamed Farghaly, Prathamesh Pathak, Ashok Natarajan, Insaf Saffar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be06a0729b344916bc03982808590ce6
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spelling	oai:doaj.org-article:be06a0729b344916bc03982808590ce62021-12-02T20:15:23ZTreatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.1932-620310.1371/journal.pone.0254569https://doaj.org/article/be06a0729b344916bc03982808590ce62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254569https://doaj.org/toc/1932-6203<h4>Objectives</h4>To characterize the pattern of approved anti-vascular endothelial growth factor (VEGF) treatments among patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the United Arab Emirates (UAE).<h4>Method</h4>This was a retrospective, nonrandomized, observational cohort analysis of the Dubai Real-world Claims Database with a 360-day follow-up period. Adult patients diagnosed with nAMD or DME treated with ranibizumab or aflibercept for the first time were included. The primary objective was to evaluate anti-VEGF treatment patterns with respect to the proportion of patients receiving ranibizumab and aflibercept for nAMD and DME separately.<h4>Results</h4>Of the 451 patients included in the final study cohort, 83.6% and 16.4% had a diagnosis of DME (ranibizumab: 48.5%; aflibercept: 51.5%) and nAMD (ranibizumab: 40.5%; aflibercept: 59.5%), respectively, at baseline. Treatment frequency of ranibizumab/aflibercept was similar for nAMD (mean: 2.4/2.9 injections; p = 0.2389) with fewer injections in the ranibizumab cohort for DME (mean: 1.9/2.5 injections; p = 0.0002). Most patients received ≤3 anti-VEGF injections during the 360-day follow-up period. The time between consecutive treatments was large (nAMD: 73.6 days/10.5 weeks; DME: 80.5 days/11.5 weeks). Approximately 10%-13.5% of patients switched their anti-VEGF therapy. Most patients (83.8%) had a diabetes diagnosis during the follow-up period.<h4>Conclusions</h4>This real-world study provides an initial understanding of anti-VEGF treatment patterns in patients with nAMD and DME in the UAE. Treatment frequency of the 2 anti-VEGF agents assessed was similar in both patient populations. Both treatments were infrequently administered with large dosing intervals.Igor KozakAvinash GurbaxaniAmmar SafarPrasan RaoAmal MasalmehHazar AssafMohamed FarghalyPrathamesh PathakAshok NatarajanInsaf SaffarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254569 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Igor Kozak Avinash Gurbaxani Ammar Safar Prasan Rao Amal Masalmeh Hazar Assaf Mohamed Farghaly Prathamesh Pathak Ashok Natarajan Insaf Saffar Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
description	<h4>Objectives</h4>To characterize the pattern of approved anti-vascular endothelial growth factor (VEGF) treatments among patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the United Arab Emirates (UAE).<h4>Method</h4>This was a retrospective, nonrandomized, observational cohort analysis of the Dubai Real-world Claims Database with a 360-day follow-up period. Adult patients diagnosed with nAMD or DME treated with ranibizumab or aflibercept for the first time were included. The primary objective was to evaluate anti-VEGF treatment patterns with respect to the proportion of patients receiving ranibizumab and aflibercept for nAMD and DME separately.<h4>Results</h4>Of the 451 patients included in the final study cohort, 83.6% and 16.4% had a diagnosis of DME (ranibizumab: 48.5%; aflibercept: 51.5%) and nAMD (ranibizumab: 40.5%; aflibercept: 59.5%), respectively, at baseline. Treatment frequency of ranibizumab/aflibercept was similar for nAMD (mean: 2.4/2.9 injections; p = 0.2389) with fewer injections in the ranibizumab cohort for DME (mean: 1.9/2.5 injections; p = 0.0002). Most patients received ≤3 anti-VEGF injections during the 360-day follow-up period. The time between consecutive treatments was large (nAMD: 73.6 days/10.5 weeks; DME: 80.5 days/11.5 weeks). Approximately 10%-13.5% of patients switched their anti-VEGF therapy. Most patients (83.8%) had a diabetes diagnosis during the follow-up period.<h4>Conclusions</h4>This real-world study provides an initial understanding of anti-VEGF treatment patterns in patients with nAMD and DME in the UAE. Treatment frequency of the 2 anti-VEGF agents assessed was similar in both patient populations. Both treatments were infrequently administered with large dosing intervals.
format	article
author	Igor Kozak Avinash Gurbaxani Ammar Safar Prasan Rao Amal Masalmeh Hazar Assaf Mohamed Farghaly Prathamesh Pathak Ashok Natarajan Insaf Saffar
author_facet	Igor Kozak Avinash Gurbaxani Ammar Safar Prasan Rao Amal Masalmeh Hazar Assaf Mohamed Farghaly Prathamesh Pathak Ashok Natarajan Insaf Saffar
author_sort	Igor Kozak
title	Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
title_short	Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
title_full	Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
title_fullStr	Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
title_full_unstemmed	Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.
title_sort	treatment patterns in patients with age-related macular degeneration and diabetic macular edema: a real-world claims analysis in dubai.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/be06a0729b344916bc03982808590ce6
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Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.

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