Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension

Xing-De Wang,1 Li Zhou,1 Chao-Yu Zhu,2 Bin Chen,1 Zhong Chen,1 Li Wei2 1Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China; 2Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang XD, Zhou L, Zhu CY, Chen B, Chen Z, Wei L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	autonomic nervous system deceleration capacity of heart rate heart rate deceleration runs insulin resistance type 2 diabetes mellitus hypertension Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/be0847cf96414ce89bc3a75d7e88405c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:be0847cf96414ce89bc3a75d7e88405c
record_format	dspace
spelling	oai:doaj.org-article:be0847cf96414ce89bc3a75d7e88405c2021-12-02T05:33:42ZAutonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension1178-1998https://doaj.org/article/be0847cf96414ce89bc3a75d7e88405c2018-07-01T00:00:00Zhttps://www.dovepress.com/autonomic-function-as-indicated-by-heart-rate-deceleration-capacity-an-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xing-De Wang,1 Li Zhou,1 Chao-Yu Zhu,2 Bin Chen,1 Zhong Chen,1 Li Wei2 1Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China; 2Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Purpose: Sympathovagal imbalance is a common underlying disorder in hypertension and diabetes. This study characterized autonomic nervous system function, indicated by heart rate deceleration capacity (DC) and deceleration runs (DRs), in patients with type 2 diabetes mellitus (T2DM), with or without concomitant essential hypertension. Subjects and methods: We recruited 50 healthy subjects, 50 patients with T2DM, and 95 with T2DM and essential hypertension. DC, DRs (DR2, DR4, and DR8, ie, episodes of 2, 4, or 8 consecutive beat-to-beat heart rate decelerations, respectively), and heart rate variability were determined by dynamic electrocardiogram. Biochemical markers of glucose and lipid metabolism, including glycated hemoglobin (HbA1c) and high-density lipoprotein cholesterol (HDL-C), were measured from blood samples. Results: Both T2DM groups featured lower DC, SD of all normal-to-normal sinus RR intervals over 24 h (SDNN), root mean square of the successive normal sinus RR interval difference, and all DR values, but higher average heart rate (AHR) and acceleration capacity (AC), than healthy subjects. There were significant associations between the following: DC and HbA1c, systolic blood pressure (SBP), AHR, age, and HDL-C; DR2 and AHR, SBP, and HbA1c; DR4 and HbA1c, age, SBP, and HDL-C; and DR8 and HbA1c, AHR, and age. In both T2DM groups, HbA1c correlated negatively with DC, DR2, and SDNN, and positively with AC and AHR; homeostasis model assessment-insulin resistance index correlated negatively with DC, all DRs, and SDNN, and positively with AC. Conclusion: Compared with healthy subjects, T2DM patients with or without essential hypertension have lower DC and DRs. DC and DRs correlate negatively with blood glucose and insulin resistance index. Keywords: autonomic nervous system, deceleration capacity of heart rate, heart rate deceleration runs, insulin resistance, type 2 diabetes mellitus, hypertensionWang XDZhou LZhu CYChen BChen ZWei LDove Medical Pressarticleautonomic nervous systemdeceleration capacity of heart rateheart rate deceleration runsinsulin resistancetype 2 diabetes mellitushypertensionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1169-1176 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	autonomic nervous system deceleration capacity of heart rate heart rate deceleration runs insulin resistance type 2 diabetes mellitus hypertension Geriatrics RC952-954.6
spellingShingle	autonomic nervous system deceleration capacity of heart rate heart rate deceleration runs insulin resistance type 2 diabetes mellitus hypertension Geriatrics RC952-954.6 Wang XD Zhou L Zhu CY Chen B Chen Z Wei L Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
description	Xing-De Wang,1 Li Zhou,1 Chao-Yu Zhu,2 Bin Chen,1 Zhong Chen,1 Li Wei2 1Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China; 2Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Purpose: Sympathovagal imbalance is a common underlying disorder in hypertension and diabetes. This study characterized autonomic nervous system function, indicated by heart rate deceleration capacity (DC) and deceleration runs (DRs), in patients with type 2 diabetes mellitus (T2DM), with or without concomitant essential hypertension. Subjects and methods: We recruited 50 healthy subjects, 50 patients with T2DM, and 95 with T2DM and essential hypertension. DC, DRs (DR2, DR4, and DR8, ie, episodes of 2, 4, or 8 consecutive beat-to-beat heart rate decelerations, respectively), and heart rate variability were determined by dynamic electrocardiogram. Biochemical markers of glucose and lipid metabolism, including glycated hemoglobin (HbA1c) and high-density lipoprotein cholesterol (HDL-C), were measured from blood samples. Results: Both T2DM groups featured lower DC, SD of all normal-to-normal sinus RR intervals over 24 h (SDNN), root mean square of the successive normal sinus RR interval difference, and all DR values, but higher average heart rate (AHR) and acceleration capacity (AC), than healthy subjects. There were significant associations between the following: DC and HbA1c, systolic blood pressure (SBP), AHR, age, and HDL-C; DR2 and AHR, SBP, and HbA1c; DR4 and HbA1c, age, SBP, and HDL-C; and DR8 and HbA1c, AHR, and age. In both T2DM groups, HbA1c correlated negatively with DC, DR2, and SDNN, and positively with AC and AHR; homeostasis model assessment-insulin resistance index correlated negatively with DC, all DRs, and SDNN, and positively with AC. Conclusion: Compared with healthy subjects, T2DM patients with or without essential hypertension have lower DC and DRs. DC and DRs correlate negatively with blood glucose and insulin resistance index. Keywords: autonomic nervous system, deceleration capacity of heart rate, heart rate deceleration runs, insulin resistance, type 2 diabetes mellitus, hypertension
format	article
author	Wang XD Zhou L Zhu CY Chen B Chen Z Wei L
author_facet	Wang XD Zhou L Zhu CY Chen B Chen Z Wei L
author_sort	Wang XD
title	Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
title_short	Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
title_full	Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
title_fullStr	Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
title_full_unstemmed	Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
title_sort	autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/be0847cf96414ce89bc3a75d7e88405c
work_keys_str_mv	AT wangxd autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension AT zhoul autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension AT zhucy autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension AT chenb autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension AT chenz autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension AT weil autonomicfunctionasindicatedbyheartratedecelerationcapacityanddecelerationrunsintype2diabetespatientswithorwithoutessentialhypertension
_version_	1718400372922384384

Autonomic function as indicated by heart rate deceleration capacity and deceleration runs in type 2 diabetes patients with or without essential hypertension

Ejemplares similares