Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance

Abstract Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to host defense in non-communicable lung inflammation remain elusive. We...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julia D. Boehme, Sabine Stegemann-Koniszewski, Andrea Autengruber, Nicole Peters, Josef Wissing, Lothar Jänsch, Andreas Jeron, Dunja Bruder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be0cd7358bc446c0b62decb32be46e70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:be0cd7358bc446c0b62decb32be46e70
record_format	dspace
spelling	oai:doaj.org-article:be0cd7358bc446c0b62decb32be46e702021-12-02T11:41:09ZChronic lung inflammation primes humoral immunity and augments antipneumococcal resistance10.1038/s41598-017-05212-42045-2322https://doaj.org/article/be0cd7358bc446c0b62decb32be46e702017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05212-4https://doaj.org/toc/2045-2322Abstract Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to host defense in non-communicable lung inflammation remain elusive. We dissected pulmonary defense against Streptococcus pneumoniae in hosts with pre-existing inflammatory conditions (SPC-HAxTCR-HA mice). Lung tissue transcriptomics and bronchoalveolar lavage fluid (BALF) proteomics revealed an induction of humoral defense mechanisms in inflamed lungs. Accordingly, besides antibacterial proteins and complement components being overrepresented in inflamed lungs, elevated polymeric immunoglobulin receptor (pIgR)-expression in AECs correlated with increased secretory immunoglobulin (SIg) transport. Consequently, opsonization assays revealed augmented pneumococcal coverage by SIgs present in the BALF of SPC-HAxTCR-HA mice, which was associated with enhanced antipneumococcal resistance. These findings emphasize the immunologic potential of AECs as well as their central role in providing antibacterial protection and put forward pIgR as potential target for therapeutic manipulation in infection-prone individuals.Julia D. BoehmeSabine Stegemann-KoniszewskiAndrea AutengruberNicole PetersJosef WissingLothar JänschAndreas JeronDunja BruderNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia D. Boehme Sabine Stegemann-Koniszewski Andrea Autengruber Nicole Peters Josef Wissing Lothar Jänsch Andreas Jeron Dunja Bruder Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
description	Abstract Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to host defense in non-communicable lung inflammation remain elusive. We dissected pulmonary defense against Streptococcus pneumoniae in hosts with pre-existing inflammatory conditions (SPC-HAxTCR-HA mice). Lung tissue transcriptomics and bronchoalveolar lavage fluid (BALF) proteomics revealed an induction of humoral defense mechanisms in inflamed lungs. Accordingly, besides antibacterial proteins and complement components being overrepresented in inflamed lungs, elevated polymeric immunoglobulin receptor (pIgR)-expression in AECs correlated with increased secretory immunoglobulin (SIg) transport. Consequently, opsonization assays revealed augmented pneumococcal coverage by SIgs present in the BALF of SPC-HAxTCR-HA mice, which was associated with enhanced antipneumococcal resistance. These findings emphasize the immunologic potential of AECs as well as their central role in providing antibacterial protection and put forward pIgR as potential target for therapeutic manipulation in infection-prone individuals.
format	article
author	Julia D. Boehme Sabine Stegemann-Koniszewski Andrea Autengruber Nicole Peters Josef Wissing Lothar Jänsch Andreas Jeron Dunja Bruder
author_facet	Julia D. Boehme Sabine Stegemann-Koniszewski Andrea Autengruber Nicole Peters Josef Wissing Lothar Jänsch Andreas Jeron Dunja Bruder
author_sort	Julia D. Boehme
title	Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
title_short	Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
title_full	Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
title_fullStr	Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
title_full_unstemmed	Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
title_sort	chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/be0cd7358bc446c0b62decb32be46e70
work_keys_str_mv	AT juliadboehme chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT sabinestegemannkoniszewski chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT andreaautengruber chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT nicolepeters chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT josefwissing chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT lotharjansch chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT andreasjeron chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance AT dunjabruder chroniclunginflammationprimeshumoralimmunityandaugmentsantipneumococcalresistance
_version_	1718395482817953792

Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance

Ejemplares similares