Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature

Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial...

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Auteurs principaux:	Ming Jiang, Li-Fen Yang, Jun Zheng, Zhuang-Gui Chen, Bo Peng
Format:	article
Langue:	EN
Publié:	Taylor & Francis Group 2020
Sujets:	metabolomics maltose aeromonas sobrial crucian carp immune response Infectious and parasitic diseases RC109-216
Accès en ligne:	https://doaj.org/article/be0f81356bba45c6b9a359f30f3b551b
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spelling	oai:doaj.org-article:be0f81356bba45c6b9a359f30f3b551b2021-11-17T14:21:58ZMaltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature2150-55942150-560810.1080/21505594.2020.1787604https://doaj.org/article/be0f81356bba45c6b9a359f30f3b551b2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1787604https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial infection and found that crucian carp was more susceptible when grown at 33°C. These distinct susceptibilities of fish at different temperatures to infection may partially be explained by their differences in the metabolism as revealed by comparative metabolomics profiling: crucian carp demonstrated enhanced TCA cycle but reduced fatty acid biosynthesis; Our study also found that maltose was the most suppressed metabolite in fish grown at 33°C. Importantly, exogenous injection of maltose enhances crucian carp survival grown at 33°C by 30%. Further study showed that exogenous maltose downregulated the production of several cytokines but enhanced the lysozyme (lyz) and complement component c3, which involves the humoral innate immunity. Our results suggest that maltose promotes the survival of crucian carp likely through fine tuning the immune gene expression, and this finding provides a novel approach to manage bacterial infection.Ming JiangLi-Fen YangJun ZhengZhuang-Gui ChenBo PengTaylor & Francis Grouparticlemetabolomicsmaltoseaeromonas sobrialcrucian carpimmune responseInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 877-888 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics maltose aeromonas sobrial crucian carp immune response Infectious and parasitic diseases RC109-216
spellingShingle	metabolomics maltose aeromonas sobrial crucian carp immune response Infectious and parasitic diseases RC109-216 Ming Jiang Li-Fen Yang Jun Zheng Zhuang-Gui Chen Bo Peng Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
description	Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial infection and found that crucian carp was more susceptible when grown at 33°C. These distinct susceptibilities of fish at different temperatures to infection may partially be explained by their differences in the metabolism as revealed by comparative metabolomics profiling: crucian carp demonstrated enhanced TCA cycle but reduced fatty acid biosynthesis; Our study also found that maltose was the most suppressed metabolite in fish grown at 33°C. Importantly, exogenous injection of maltose enhances crucian carp survival grown at 33°C by 30%. Further study showed that exogenous maltose downregulated the production of several cytokines but enhanced the lysozyme (lyz) and complement component c3, which involves the humoral innate immunity. Our results suggest that maltose promotes the survival of crucian carp likely through fine tuning the immune gene expression, and this finding provides a novel approach to manage bacterial infection.
format	article
author	Ming Jiang Li-Fen Yang Jun Zheng Zhuang-Gui Chen Bo Peng
author_facet	Ming Jiang Li-Fen Yang Jun Zheng Zhuang-Gui Chen Bo Peng
author_sort	Ming Jiang
title	Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_short	Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_full	Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_fullStr	Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_full_unstemmed	Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_sort	maltose promotes crucian carp survival against aeromonas sobrial infection at high temperature
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/be0f81356bba45c6b9a359f30f3b551b
work_keys_str_mv	AT mingjiang maltosepromotescruciancarpsurvivalagainstaeromonassobrialinfectionathightemperature AT lifenyang maltosepromotescruciancarpsurvivalagainstaeromonassobrialinfectionathightemperature AT junzheng maltosepromotescruciancarpsurvivalagainstaeromonassobrialinfectionathightemperature AT zhuangguichen maltosepromotescruciancarpsurvivalagainstaeromonassobrialinfectionathightemperature AT bopeng maltosepromotescruciancarpsurvivalagainstaeromonassobrialinfectionathightemperature
_version_	1718425506861285376

Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature

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