IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.

<h4>Background</h4>Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to establish biomarkers associated wi...

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Autores principales:	Lisa F P Ng, Angela Chow, Yong-Jiang Sun, Dyan J C Kwek, Poh-Lian Lim, Frederico Dimatatac, Lee-Ching Ng, Eng-Eong Ooi, Khar-Heng Choo, Zhisheng Her, Philippe Kourilsky, Yee-Sin Leo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be13d69a4f7349cfb9001a109c5fd7b5
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spelling	oai:doaj.org-article:be13d69a4f7349cfb9001a109c5fd7b52021-11-25T06:17:42ZIL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.1932-620310.1371/journal.pone.0004261https://doaj.org/article/be13d69a4f7349cfb9001a109c5fd7b52009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19156204/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to establish biomarkers associated with infection and/or disease severity.<h4>Methods and findings</h4>Adult patients with laboratory-confirmed Chikungunya fever infection, who were referred to the Communicable Disease Centre/Tan Tock Seng Hospital during the period from January to February 2008, were included in this retrospective study. Plasma fractions were analyzed using a multiplex-microbead immunoassay. Among the patients, the most common clinical features were fever (100%), arthralgia (90%), rash (50%) and conjunctivitis (40%). Profiles of 30 cytokines, chemokines, and growth factors were able to discriminate the clinical forms of Chikungunya from healthy controls, with patients classified as non-severe and severe disease. Levels of 8 plasma cytokines and 4 growth factors were significantly elevated. Statistical analysis showed that an increase in IL-1beta, IL-6 and a decrease in RANTES were associated with disease severity.<h4>Conclusions</h4>This is the first comprehensive report on the production of cytokines, chemokines, and growth factors during acute Chikungunya virus infection. Using these biomarkers, we were able to distinguish between mild disease and more severe forms of Chikungunya fever, thus enabling the identification of patients with poor prognosis and monitoring of the disease.Lisa F P NgAngela ChowYong-Jiang SunDyan J C KwekPoh-Lian LimFrederico DimatatacLee-Ching NgEng-Eong OoiKhar-Heng ChooZhisheng HerPhilippe KourilskyYee-Sin LeoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 1, p e4261 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa F P Ng Angela Chow Yong-Jiang Sun Dyan J C Kwek Poh-Lian Lim Frederico Dimatatac Lee-Ching Ng Eng-Eong Ooi Khar-Heng Choo Zhisheng Her Philippe Kourilsky Yee-Sin Leo IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
description	<h4>Background</h4>Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to establish biomarkers associated with infection and/or disease severity.<h4>Methods and findings</h4>Adult patients with laboratory-confirmed Chikungunya fever infection, who were referred to the Communicable Disease Centre/Tan Tock Seng Hospital during the period from January to February 2008, were included in this retrospective study. Plasma fractions were analyzed using a multiplex-microbead immunoassay. Among the patients, the most common clinical features were fever (100%), arthralgia (90%), rash (50%) and conjunctivitis (40%). Profiles of 30 cytokines, chemokines, and growth factors were able to discriminate the clinical forms of Chikungunya from healthy controls, with patients classified as non-severe and severe disease. Levels of 8 plasma cytokines and 4 growth factors were significantly elevated. Statistical analysis showed that an increase in IL-1beta, IL-6 and a decrease in RANTES were associated with disease severity.<h4>Conclusions</h4>This is the first comprehensive report on the production of cytokines, chemokines, and growth factors during acute Chikungunya virus infection. Using these biomarkers, we were able to distinguish between mild disease and more severe forms of Chikungunya fever, thus enabling the identification of patients with poor prognosis and monitoring of the disease.
format	article
author	Lisa F P Ng Angela Chow Yong-Jiang Sun Dyan J C Kwek Poh-Lian Lim Frederico Dimatatac Lee-Ching Ng Eng-Eong Ooi Khar-Heng Choo Zhisheng Her Philippe Kourilsky Yee-Sin Leo
author_facet	Lisa F P Ng Angela Chow Yong-Jiang Sun Dyan J C Kwek Poh-Lian Lim Frederico Dimatatac Lee-Ching Ng Eng-Eong Ooi Khar-Heng Choo Zhisheng Her Philippe Kourilsky Yee-Sin Leo
author_sort	Lisa F P Ng
title	IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
title_short	IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
title_full	IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
title_fullStr	IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
title_full_unstemmed	IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.
title_sort	il-1beta, il-6, and rantes as biomarkers of chikungunya severity.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/be13d69a4f7349cfb9001a109c5fd7b5
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IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.

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