EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent

Xiaoling Li,1 Xianlong Ye,2 Jianying Qi,2 Rangrang Fan,1 Xiang Gao,1 Yunzhou Wu,2 Liangxue Zhou,1 Aiping Tong,1 Gang Guo1 1State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Ch...

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Autores principales:	Li X, Ye X, Qi J, Fan R, Gao X, Wu Y, Zhou L, Tong A, Guo G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epidermal Growth Factor EGF Curcumin Wound Healing Thermosensitive Hydrogel Nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/be172aadbfbe498b994264142ccd344d
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spelling	oai:doaj.org-article:be172aadbfbe498b994264142ccd344d2021-12-02T05:02:05ZEGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent1178-2013https://doaj.org/article/be172aadbfbe498b994264142ccd344d2016-08-01T00:00:00Zhttps://www.dovepress.com/egf-and-curcumin-co-encapsulated-nanoparticlehydrogel-system-as-potent-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoling Li,1 Xianlong Ye,2 Jianying Qi,2 Rangrang Fan,1 Xiang Gao,1 Yunzhou Wu,2 Liangxue Zhou,1 Aiping Tong,1 Gang Guo1 1State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2College of Life Science, Northeast Agriculture University, Harbin, People’s Republic of China Abstract: Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process generally inhibits repair of the injured tissues. Topical applications of antioxidants like curcumin (Cur) could protect tissues from oxidative damage and significantly improve tissue remodeling. To achieve much accelerated wound healing effects, we designed a novel dual drug co-loaded in situ gel-forming nanoparticle/hydrogel system (EGF-Cur-NP/H) which acted not only as a supportive matrix for the regenerative tissue, but also as a sustained drug depot for EGF and Cur. In the established excisional full-thickness wound model, EGF-Cur-NP/H treatment significantly enhanced wound closure through increasing granulation tissue formation, collagen deposition, and angiogenesis, relative to normal saline, nanoparticle/hydrogel (NP/H), Cur-NP/H, and EGF-NP/H treated groups. In conclusion, this study provides a biocompatible in situ gel-forming system for efficient topical application of EGF and Cur in the landscape of tissue repair. Keywords: epidermal growth factor, EGF, curcumin, wound healing, thermosensitive hydrogel, nanoparticles Li XYe XQi JFan RGao XWu YZhou LTong AGuo GDove Medical PressarticleEpidermal Growth FactorEGFCurcuminWound HealingThermosensitive HydrogelNanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 3993-4009 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epidermal Growth Factor EGF Curcumin Wound Healing Thermosensitive Hydrogel Nanoparticles Medicine (General) R5-920
spellingShingle	Epidermal Growth Factor EGF Curcumin Wound Healing Thermosensitive Hydrogel Nanoparticles Medicine (General) R5-920 Li X Ye X Qi J Fan R Gao X Wu Y Zhou L Tong A Guo G EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
description	Xiaoling Li,1 Xianlong Ye,2 Jianying Qi,2 Rangrang Fan,1 Xiang Gao,1 Yunzhou Wu,2 Liangxue Zhou,1 Aiping Tong,1 Gang Guo1 1State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2College of Life Science, Northeast Agriculture University, Harbin, People’s Republic of China Abstract: Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process generally inhibits repair of the injured tissues. Topical applications of antioxidants like curcumin (Cur) could protect tissues from oxidative damage and significantly improve tissue remodeling. To achieve much accelerated wound healing effects, we designed a novel dual drug co-loaded in situ gel-forming nanoparticle/hydrogel system (EGF-Cur-NP/H) which acted not only as a supportive matrix for the regenerative tissue, but also as a sustained drug depot for EGF and Cur. In the established excisional full-thickness wound model, EGF-Cur-NP/H treatment significantly enhanced wound closure through increasing granulation tissue formation, collagen deposition, and angiogenesis, relative to normal saline, nanoparticle/hydrogel (NP/H), Cur-NP/H, and EGF-NP/H treated groups. In conclusion, this study provides a biocompatible in situ gel-forming system for efficient topical application of EGF and Cur in the landscape of tissue repair. Keywords: epidermal growth factor, EGF, curcumin, wound healing, thermosensitive hydrogel, nanoparticles
format	article
author	Li X Ye X Qi J Fan R Gao X Wu Y Zhou L Tong A Guo G
author_facet	Li X Ye X Qi J Fan R Gao X Wu Y Zhou L Tong A Guo G
author_sort	Li X
title	EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
title_short	EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
title_full	EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
title_fullStr	EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
title_full_unstemmed	EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
title_sort	egf and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/be172aadbfbe498b994264142ccd344d
work_keys_str_mv	AT lix egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT yex egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT qij egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT fanr egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT gaox egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT wuy egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT zhoul egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT tonga egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent AT guog egfandcurcumincoencapsulatednanoparticlehydrogelsystemaspotentskinregenerationagent
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EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent

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