Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.

Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.

The role of Tau phosphorylation in neurofibrillary degeneration linked to Alzheimer's disease remains to be established. While transgenic mice based on FTDP-17 Tau mutations recapitulate hallmarks of neurofibrillary degeneration, cell models could be helpful for exploratory studies on molecular...

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Autores principales: Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Buée
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/be175fede5414d1c891f064a9fc359ad
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