Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial

Introduction: Surgical site infection (SSI) is caused by cesarean section in the hospital and its prevalence in the studies is up to 16%. Objectives: This study aimed to compare the rate of infection in women undergoing cesarean section. Oral clindamycin and cefalexin were administered for 48 hours...

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Autores principales:	Farzaneh Broumand, Naghmeh Zand Vakili, Zahra Yekta, Shabnam Vazifekhah
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	superficial infection deep infection pelvic infection cesarean Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/be18b11691914cc3809cac5d3b9944f6
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spelling	oai:doaj.org-article:be18b11691914cc3809cac5d3b9944f62021-11-16T10:42:13ZComparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial2476-393410.34172/jpe.2022.07https://doaj.org/article/be18b11691914cc3809cac5d3b9944f62022-01-01T00:00:00Zhttps://jprevepi.com/PDF/jpe-7-e07.pdfhttps://doaj.org/toc/2476-3934Introduction: Surgical site infection (SSI) is caused by cesarean section in the hospital and its prevalence in the studies is up to 16%. Objectives: This study aimed to compare the rate of infection in women undergoing cesarean section. Oral clindamycin and cefalexin were administered for 48 hours as prophylactic antibiotics. Patients and Methods: In this clinical trial study, women with emergency cesarean section were divided into two groups. Intervention was oral administration of cefalexin 500mg every 6 hours and clindamycin 300 mg every 6 hours for 48 hours. All participants were referred to the gynecology center on day 7–10, at the time of removal of the sutures, and within 30 days after cesarean section, to assess the presence or absence of wound infection after surgery during 30 days. Results: In this clinical trial study, 462 pregnant women undergoing cesarean section were enrolled in the intervention and control groups. Of 231 patients in the intervention group, 15 women (6.5%) had cesarean section infection (13 cases with superficial, and 2 cases with deep infection). In the control group, 45 cases (19.5%) had cesarean section infection (31 cases with superficial, 10 cases with deep, and 4 cases with developed pelvic infection) (P = 0.001). Age, pre-cesarean length of stay, pre-term incision, type of incision, discharge longer than 18 hours after cesarean section, and maternal diabetes were significantly different regarding cesarean section infection in both groups. The frequency of cesarean section infection was less in the intervention group (P <0.001). Conclusion: Administration of prophylactic antibiotic can have a significant role in reducing cesarean section infection. Trial Registration: Registration of trial protocol has been approved in Thailand registry of clinical trials (identifier: TCTR20201204002, http://www.clinicaltrials.in.th/index.php?tp=regtrials & menu=trialsearch & s-menu=fulltext & task=search & task2=view1 & id=7120, ethical code; IR.UMSU.REC.1397.323).Farzaneh BroumandNaghmeh Zand VakiliZahra YektaShabnam VazifekhahSociety of Diabetic Nephropathy Preventionarticlesuperficial infectiondeep infectionpelvic infectioncesareanSpecialties of internal medicineRC581-951Infectious and parasitic diseasesRC109-216ENJournal of Preventive Epidemiology, Vol 7, Iss 1, Pp e07-e07 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	superficial infection deep infection pelvic infection cesarean Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
spellingShingle	superficial infection deep infection pelvic infection cesarean Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216 Farzaneh Broumand Naghmeh Zand Vakili Zahra Yekta Shabnam Vazifekhah Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
description	Introduction: Surgical site infection (SSI) is caused by cesarean section in the hospital and its prevalence in the studies is up to 16%. Objectives: This study aimed to compare the rate of infection in women undergoing cesarean section. Oral clindamycin and cefalexin were administered for 48 hours as prophylactic antibiotics. Patients and Methods: In this clinical trial study, women with emergency cesarean section were divided into two groups. Intervention was oral administration of cefalexin 500mg every 6 hours and clindamycin 300 mg every 6 hours for 48 hours. All participants were referred to the gynecology center on day 7–10, at the time of removal of the sutures, and within 30 days after cesarean section, to assess the presence or absence of wound infection after surgery during 30 days. Results: In this clinical trial study, 462 pregnant women undergoing cesarean section were enrolled in the intervention and control groups. Of 231 patients in the intervention group, 15 women (6.5%) had cesarean section infection (13 cases with superficial, and 2 cases with deep infection). In the control group, 45 cases (19.5%) had cesarean section infection (31 cases with superficial, 10 cases with deep, and 4 cases with developed pelvic infection) (P = 0.001). Age, pre-cesarean length of stay, pre-term incision, type of incision, discharge longer than 18 hours after cesarean section, and maternal diabetes were significantly different regarding cesarean section infection in both groups. The frequency of cesarean section infection was less in the intervention group (P <0.001). Conclusion: Administration of prophylactic antibiotic can have a significant role in reducing cesarean section infection. Trial Registration: Registration of trial protocol has been approved in Thailand registry of clinical trials (identifier: TCTR20201204002, http://www.clinicaltrials.in.th/index.php?tp=regtrials & menu=trialsearch & s-menu=fulltext & task=search & task2=view1 & id=7120, ethical code; IR.UMSU.REC.1397.323).
format	article
author	Farzaneh Broumand Naghmeh Zand Vakili Zahra Yekta Shabnam Vazifekhah
author_facet	Farzaneh Broumand Naghmeh Zand Vakili Zahra Yekta Shabnam Vazifekhah
author_sort	Farzaneh Broumand
title	Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
title_short	Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
title_full	Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
title_fullStr	Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
title_full_unstemmed	Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
title_sort	comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/be18b11691914cc3809cac5d3b9944f6
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Comparative study of surgical site infection with or without post cesarean prophylactic oral antibiotics; a single-blinded randomized clinical trial

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