EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS

The aim of this study was to assess optimizing effects of antistress neurotechnologies on the clinical course of acute pulmonary tuberculosis. The study was performed in three steps: upon admission before treatment, followed by repeated examination at 2 and 4 months. The patients before study were d...

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Autores principales:	O. V. Kolesnikova, T. I. Petrenko, T. A. Kolpakova, V. A. Trufakin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	pulmonary tuberculosis antistress therapy immune system phagocytosis nk cells cd16+ lung destruction foci Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/be18c5d81242425ea052bec8a50a7c58
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spelling	oai:doaj.org-article:be18c5d81242425ea052bec8a50a7c582021-11-18T08:03:48ZEFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2019-1-129-136https://doaj.org/article/be18c5d81242425ea052bec8a50a7c582019-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1706https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this study was to assess optimizing effects of antistress neurotechnologies on the clinical course of acute pulmonary tuberculosis. The study was performed in three steps: upon admission before treatment, followed by repeated examination at 2 and 4 months. The patients before study were divided into the two groups: (1) 33 patients received standard antituberculosis drug therapy (SDT) and (2) 35 cases after standard antituberculosis drug therapy accompanied by neurothechnological anti-stress therapy (NAT). Patients from the NAT group received a regular audio-visual-vibrotactile stimulation as additional therapy (2 to 3 30-min sessions per week during 4 months). By the time of hospitalization, the groups did not differ in their general immune state. The percentages of CD3+ , CD4+ , CD8+ , CD16+ , CD19+ as well as indexes of phagocyte activity showed some changes after 2 and 4 months of therapy. The patients from both groups before treatment exhibited lymphocytosis, decreased phagocyte activity, when compared to healthy individuals. By the end of therapy (4 months), the patients from the NAT group showed increased phagocytosis by monocytes (p < 0.01) and granulocytes (p < 0.05) which approached values of healthy control. The study demonstrated also that efficiency of combined therapy was higher in the NAT vs. SDT group: closure of lung destruction cavities was observed in 90.5% of patients from the NAT group vs 45% of patients from the STD group. The results present evidence for combined implementation of neurothechnological anti-stress therapies as a supplementary method for the standard specific drug therapy in primary infiltrative lung tuberculosis.O. V. KolesnikovaT. I. PetrenkoT. A. KolpakovaV. A. TrufakinSPb RAACIarticlepulmonary tuberculosisantistress therapyimmune systemphagocytosisnk cellscd16+lung destruction fociImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 1, Pp 129-136 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	pulmonary tuberculosis antistress therapy immune system phagocytosis nk cells cd16+ lung destruction foci Immunologic diseases. Allergy RC581-607
spellingShingle	pulmonary tuberculosis antistress therapy immune system phagocytosis nk cells cd16+ lung destruction foci Immunologic diseases. Allergy RC581-607 O. V. Kolesnikova T. I. Petrenko T. A. Kolpakova V. A. Trufakin EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
description	The aim of this study was to assess optimizing effects of antistress neurotechnologies on the clinical course of acute pulmonary tuberculosis. The study was performed in three steps: upon admission before treatment, followed by repeated examination at 2 and 4 months. The patients before study were divided into the two groups: (1) 33 patients received standard antituberculosis drug therapy (SDT) and (2) 35 cases after standard antituberculosis drug therapy accompanied by neurothechnological anti-stress therapy (NAT). Patients from the NAT group received a regular audio-visual-vibrotactile stimulation as additional therapy (2 to 3 30-min sessions per week during 4 months). By the time of hospitalization, the groups did not differ in their general immune state. The percentages of CD3+ , CD4+ , CD8+ , CD16+ , CD19+ as well as indexes of phagocyte activity showed some changes after 2 and 4 months of therapy. The patients from both groups before treatment exhibited lymphocytosis, decreased phagocyte activity, when compared to healthy individuals. By the end of therapy (4 months), the patients from the NAT group showed increased phagocytosis by monocytes (p < 0.01) and granulocytes (p < 0.05) which approached values of healthy control. The study demonstrated also that efficiency of combined therapy was higher in the NAT vs. SDT group: closure of lung destruction cavities was observed in 90.5% of patients from the NAT group vs 45% of patients from the STD group. The results present evidence for combined implementation of neurothechnological anti-stress therapies as a supplementary method for the standard specific drug therapy in primary infiltrative lung tuberculosis.
format	article
author	O. V. Kolesnikova T. I. Petrenko T. A. Kolpakova V. A. Trufakin
author_facet	O. V. Kolesnikova T. I. Petrenko T. A. Kolpakova V. A. Trufakin
author_sort	O. V. Kolesnikova
title	EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
title_short	EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
title_full	EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
title_fullStr	EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
title_full_unstemmed	EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS
title_sort	effects of psychophysiological neurotherapy in regulation immune response combined with standard antituberculosis drug therapy in acute pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/be18c5d81242425ea052bec8a50a7c58
work_keys_str_mv	AT ovkolesnikova effectsofpsychophysiologicalneurotherapyinregulationimmuneresponsecombinedwithstandardantituberculosisdrugtherapyinacutepulmonarytuberculosis AT tipetrenko effectsofpsychophysiologicalneurotherapyinregulationimmuneresponsecombinedwithstandardantituberculosisdrugtherapyinacutepulmonarytuberculosis AT takolpakova effectsofpsychophysiologicalneurotherapyinregulationimmuneresponsecombinedwithstandardantituberculosisdrugtherapyinacutepulmonarytuberculosis AT vatrufakin effectsofpsychophysiologicalneurotherapyinregulationimmuneresponsecombinedwithstandardantituberculosisdrugtherapyinacutepulmonarytuberculosis
_version_	1718422377601171456

EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS

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