Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40

Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with Roquin using structural and biochemical techniques.

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Autores principales:	Robert Janowski, Gitta A. Heinz, Andreas Schlundt, Nina Wommelsdorf, Sven Brenner, Andreas R. Gruber, Michael Blank, Thorsten Buch, Raymund Buhmann, Mihaela Zavolan, Dierk Niessing, Vigo Heissmeyer, Michael Sattler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be1a189912b647edb8ff00db7603f09a
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spelling	oai:doaj.org-article:be1a189912b647edb8ff00db7603f09a2021-12-02T16:57:49ZRoquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox4010.1038/ncomms110322041-1723https://doaj.org/article/be1a189912b647edb8ff00db7603f09a2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11032https://doaj.org/toc/2041-1723Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with Roquin using structural and biochemical techniques.Robert JanowskiGitta A. HeinzAndreas SchlundtNina WommelsdorfSven BrennerAndreas R. GruberMichael BlankThorsten BuchRaymund BuhmannMihaela ZavolanDierk NiessingVigo HeissmeyerMichael SattlerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert Janowski Gitta A. Heinz Andreas Schlundt Nina Wommelsdorf Sven Brenner Andreas R. Gruber Michael Blank Thorsten Buch Raymund Buhmann Mihaela Zavolan Dierk Niessing Vigo Heissmeyer Michael Sattler Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
description	Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with Roquin using structural and biochemical techniques.
format	article
author	Robert Janowski Gitta A. Heinz Andreas Schlundt Nina Wommelsdorf Sven Brenner Andreas R. Gruber Michael Blank Thorsten Buch Raymund Buhmann Mihaela Zavolan Dierk Niessing Vigo Heissmeyer Michael Sattler
author_facet	Robert Janowski Gitta A. Heinz Andreas Schlundt Nina Wommelsdorf Sven Brenner Andreas R. Gruber Michael Blank Thorsten Buch Raymund Buhmann Mihaela Zavolan Dierk Niessing Vigo Heissmeyer Michael Sattler
author_sort	Robert Janowski
title	Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
title_short	Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
title_full	Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
title_fullStr	Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
title_full_unstemmed	Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
title_sort	roquin recognizes a non-canonical hexaloop structure in the 3′-utr of ox40
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/be1a189912b647edb8ff00db7603f09a
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Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40

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