Structure of the p53/RNA polymerase II assembly
Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression...
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Nature Portfolio
2021
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oai:doaj.org-article:be1a87333b6a4982b660b7ba76442e682021-12-02T13:24:25ZStructure of the p53/RNA polymerase II assembly10.1038/s42003-021-01934-42399-3642https://doaj.org/article/be1a87333b6a4982b660b7ba76442e682021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01934-4https://doaj.org/toc/2399-3642Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression.Shu-Hao LiouSameer K. SinghRobert H. SingerRobert A. ColemanWei-Li LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
institution |
DOAJ |
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DOAJ |
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EN |
topic |
Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Shu-Hao Liou Sameer K. Singh Robert H. Singer Robert A. Coleman Wei-Li Liu Structure of the p53/RNA polymerase II assembly |
description |
Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression. |
format |
article |
author |
Shu-Hao Liou Sameer K. Singh Robert H. Singer Robert A. Coleman Wei-Li Liu |
author_facet |
Shu-Hao Liou Sameer K. Singh Robert H. Singer Robert A. Coleman Wei-Li Liu |
author_sort |
Shu-Hao Liou |
title |
Structure of the p53/RNA polymerase II assembly |
title_short |
Structure of the p53/RNA polymerase II assembly |
title_full |
Structure of the p53/RNA polymerase II assembly |
title_fullStr |
Structure of the p53/RNA polymerase II assembly |
title_full_unstemmed |
Structure of the p53/RNA polymerase II assembly |
title_sort |
structure of the p53/rna polymerase ii assembly |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/be1a87333b6a4982b660b7ba76442e68 |
work_keys_str_mv |
AT shuhaoliou structureofthep53rnapolymeraseiiassembly AT sameerksingh structureofthep53rnapolymeraseiiassembly AT roberthsinger structureofthep53rnapolymeraseiiassembly AT robertacoleman structureofthep53rnapolymeraseiiassembly AT weililiu structureofthep53rnapolymeraseiiassembly |
_version_ |
1718393117488447488 |