Structure of the p53/RNA polymerase II assembly

Structure of the p53/RNA polymerase II assembly

Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression...

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Auteurs principaux: Shu-Hao Liou, Sameer K. Singh, Robert H. Singer, Robert A. Coleman, Wei-Li Liu
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/be1a87333b6a4982b660b7ba76442e68
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spelling oai:doaj.org-article:be1a87333b6a4982b660b7ba76442e682021-12-02T13:24:25ZStructure of the p53/RNA polymerase II assembly10.1038/s42003-021-01934-42399-3642https://doaj.org/article/be1a87333b6a4982b660b7ba76442e682021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01934-4https://doaj.org/toc/2399-3642Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression.Shu-Hao LiouSameer K. SinghRobert H. SingerRobert A. ColemanWei-Li LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Shu-Hao Liou
Sameer K. Singh
Robert H. Singer
Robert A. Coleman
Wei-Li Liu
Structure of the p53/RNA polymerase II assembly
description Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression.
format article
author Shu-Hao Liou
Sameer K. Singh
Robert H. Singer
Robert A. Coleman
Wei-Li Liu
author_facet Shu-Hao Liou
Sameer K. Singh
Robert H. Singer
Robert A. Coleman
Wei-Li Liu
author_sort Shu-Hao Liou
title Structure of the p53/RNA polymerase II assembly
title_short Structure of the p53/RNA polymerase II assembly
title_full Structure of the p53/RNA polymerase II assembly
title_fullStr Structure of the p53/RNA polymerase II assembly
title_full_unstemmed Structure of the p53/RNA polymerase II assembly
title_sort structure of the p53/rna polymerase ii assembly
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/be1a87333b6a4982b660b7ba76442e68
work_keys_str_mv AT shuhaoliou structureofthep53rnapolymeraseiiassembly
AT sameerksingh structureofthep53rnapolymeraseiiassembly
AT roberthsinger structureofthep53rnapolymeraseiiassembly
AT robertacoleman structureofthep53rnapolymeraseiiassembly
AT weililiu structureofthep53rnapolymeraseiiassembly
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