Structure of the p53/RNA polymerase II assembly
Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression...
Saved in:
| Main Authors: | Shu-Hao Liou, Sameer K. Singh, Robert H. Singer, Robert A. Coleman, Wei-Li Liu |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/be1a87333b6a4982b660b7ba76442e68 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.
by: Yakov Korkhin, et al.
Published: (2009) -
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
by: Isaac Fianu, et al.
Published: (2021) -
Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
by: Natacha Opalka, et al.
Published: (2010) -
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing.
by: Yehuda Brody, et al.
Published: (2011) -
The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation.
by: Cecilia B Levandowski, et al.
Published: (2021)