Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promisin...

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Autores principales:	Matthias Eden, Benjamin Meder, Mirko Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, Alexander Bernt, Ashraf Rangrez, Matthias Busch, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Christophe Heymes, Wolfgang Rottbauer, Patrick Most, Franz Hofmann, Norbert Frey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be1c405ffde14645b9a55bd92869f64e
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spelling	oai:doaj.org-article:be1c405ffde14645b9a55bd92869f64e2021-12-02T15:35:44ZMyoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression10.1038/ncomms113172041-1723https://doaj.org/article/be1c405ffde14645b9a55bd92869f64e2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11317https://doaj.org/toc/2041-1723Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.Matthias EdenBenjamin MederMirko VölkersMontatip PoomvanichaKatrin DomesM. BranchereauP. MarckRainer WillAlexander BerntAshraf RangrezMatthias BuschGerman Mouse Clinic ConsortiumMartin Hrabě de AngelisChristophe HeymesWolfgang RottbauerPatrick MostFranz HofmannNorbert FreyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias Eden Benjamin Meder Mirko Völkers Montatip Poomvanicha Katrin Domes M. Branchereau P. Marck Rainer Will Alexander Bernt Ashraf Rangrez Matthias Busch German Mouse Clinic Consortium Martin Hrabě de Angelis Christophe Heymes Wolfgang Rottbauer Patrick Most Franz Hofmann Norbert Frey Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
description	Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.
format	article
author	Matthias Eden Benjamin Meder Mirko Völkers Montatip Poomvanicha Katrin Domes M. Branchereau P. Marck Rainer Will Alexander Bernt Ashraf Rangrez Matthias Busch German Mouse Clinic Consortium Martin Hrabě de Angelis Christophe Heymes Wolfgang Rottbauer Patrick Most Franz Hofmann Norbert Frey
author_facet	Matthias Eden Benjamin Meder Mirko Völkers Montatip Poomvanicha Katrin Domes M. Branchereau P. Marck Rainer Will Alexander Bernt Ashraf Rangrez Matthias Busch German Mouse Clinic Consortium Martin Hrabě de Angelis Christophe Heymes Wolfgang Rottbauer Patrick Most Franz Hofmann Norbert Frey
author_sort	Matthias Eden
title	Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
title_short	Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
title_full	Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
title_fullStr	Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
title_full_unstemmed	Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
title_sort	myoscape controls cardiac calcium cycling and contractility via regulation of l-type calcium channel surface expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/be1c405ffde14645b9a55bd92869f64e
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_version_	1718386499428286464

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

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