A minimal model for structure, dynamics, and tension of monolayered cell colonies

Cells are in constant movement inside tissues, but often remain cohesive nevertheless, i.e., single cells do not escape from the colony edges. Using an active Brownian-particle model with attraction, in this paper the authors develop an interaction potential that reproduces experimental observations...

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Autores principales: Debarati Sarkar, Gerhard Gompper, Jens Elgeti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/be1ea23d48c743c5b67f6494bec3f062
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Sumario:Cells are in constant movement inside tissues, but often remain cohesive nevertheless, i.e., single cells do not escape from the colony edges. Using an active Brownian-particle model with attraction, in this paper the authors develop an interaction potential that reproduces experimental observations describing the motion of epithelial sheets under different conditions.