Metabolomic and Lipidomic Profiling of Bone Marrow Plasma Differentiates Patients with Monoclonal Gammopathy of Undetermined Significance from Multiple Myeloma

Metabolomic and Lipidomic Profiling of Bone Marrow Plasma Differentiates Patients with Monoclonal Gammopathy of Undetermined Significance from Multiple Myeloma

Abstract Oncogenic drivers of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) such as c-MYC have downstream effects on intracellular metabolic pathways of clonal plasma cells (PCs). Thus, extracellular environments such as the bone marrow (BM) plasma...

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Autores principales: Wilson I. Gonsalves, Katarzyna Broniowska, Erik Jessen, Xuan-Mai Petterson, Alexander Graham Bush, Jaimee Gransee, Martha Q. Lacy, Taro Hitosugi, Shaji K. Kumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/be1ea48f80f147afb852802099cac5d1
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