Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors
Díaz-Carballo et al. find that HDAC inhibitors induces the expression of human endogenous retrovirus envelope genes in ovarian cancer cells, and that Toll-like receptor (TLR) 7/8 agonists act synergistically with HDAC inhibitors in triggering cancer cell apoptosis. The combination also reduces growt...
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Nature Portfolio
2021
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oai:doaj.org-article:be2335da27dd4364a60375f2a3eb24a52021-12-02T13:34:31ZEnhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors10.1038/s42003-021-01800-32399-3642https://doaj.org/article/be2335da27dd4364a60375f2a3eb24a52021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01800-3https://doaj.org/toc/2399-3642Díaz-Carballo et al. find that HDAC inhibitors induces the expression of human endogenous retrovirus envelope genes in ovarian cancer cells, and that Toll-like receptor (TLR) 7/8 agonists act synergistically with HDAC inhibitors in triggering cancer cell apoptosis. The combination also reduces growth of ovarian tumour xenografts, providing a potential rationale for future therapies.David Díaz-CarballoSahitya SakaAli H. AcikelliEkaterina HompJulia ErwesRebecca DemmigJacqueline KleinKatrin SchröerSascha MalakFlevy D’SouzaAdrien Noa-BolañoSaskia MenzeEmilio PanoSwetlana AndrioffMarc TeipelPhilip DammannDiana KleinAmber NasreenAndrea TannapfelNicole GrandiEnzo TramontanoCrista OchsenfarthDirk StrumbergNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 David Díaz-Carballo Sahitya Saka Ali H. Acikelli Ekaterina Homp Julia Erwes Rebecca Demmig Jacqueline Klein Katrin Schröer Sascha Malak Flevy D’Souza Adrien Noa-Bolaño Saskia Menze Emilio Pano Swetlana Andrioff Marc Teipel Philip Dammann Diana Klein Amber Nasreen Andrea Tannapfel Nicole Grandi Enzo Tramontano Crista Ochsenfarth Dirk Strumberg Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| description |
Díaz-Carballo et al. find that HDAC inhibitors induces the expression of human endogenous retrovirus envelope genes in ovarian cancer cells, and that Toll-like receptor (TLR) 7/8 agonists act synergistically with HDAC inhibitors in triggering cancer cell apoptosis. The combination also reduces growth of ovarian tumour xenografts, providing a potential rationale for future therapies. |
| format |
article |
| author |
David Díaz-Carballo Sahitya Saka Ali H. Acikelli Ekaterina Homp Julia Erwes Rebecca Demmig Jacqueline Klein Katrin Schröer Sascha Malak Flevy D’Souza Adrien Noa-Bolaño Saskia Menze Emilio Pano Swetlana Andrioff Marc Teipel Philip Dammann Diana Klein Amber Nasreen Andrea Tannapfel Nicole Grandi Enzo Tramontano Crista Ochsenfarth Dirk Strumberg |
| author_facet |
David Díaz-Carballo Sahitya Saka Ali H. Acikelli Ekaterina Homp Julia Erwes Rebecca Demmig Jacqueline Klein Katrin Schröer Sascha Malak Flevy D’Souza Adrien Noa-Bolaño Saskia Menze Emilio Pano Swetlana Andrioff Marc Teipel Philip Dammann Diana Klein Amber Nasreen Andrea Tannapfel Nicole Grandi Enzo Tramontano Crista Ochsenfarth Dirk Strumberg |
| author_sort |
David Díaz-Carballo |
| title |
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| title_short |
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| title_full |
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| title_fullStr |
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| title_full_unstemmed |
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors |
| title_sort |
enhanced antitumoral activity of tlr7 agonists via activation of human endogenous retroviruses by hdac inhibitors |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/be2335da27dd4364a60375f2a3eb24a5 |
| work_keys_str_mv |
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| _version_ |
1718392817927061504 |