Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis
Abstract. Background:. Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was...
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Wolters Kluwer
2021
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oai:doaj.org-article:be238f899fe14ba09be9ee71d0d762fd2021-11-25T07:57:20ZElevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis0366-69992542-564110.1097/CM9.0000000000001612https://doaj.org/article/be238f899fe14ba09be9ee71d0d762fd2021-11-01T00:00:00Zhttp://journals.lww.com/10.1097/CM9.0000000000001612https://doaj.org/toc/0366-6999https://doaj.org/toc/2542-5641Abstract. Background:. Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients. Methods:. Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 69 patients with PsA and 60 controls, including 39 rheumatoid arthritis (RA) patients, and 21 healthy controls (HCs). Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by ELISA. The association of Dkk-1 level with clinical and laboratory features of PsA was analyzed. Logistic regression analysis was used to analyze the risk factors for bone erosion in PsA. Results:. Dkk-1 was elevated in 68.1% (47/69) of the patients with PsA, 46.2% (18/39) of RA patients, and 9.5% (2/21) of HCs. Serum Dkk-1 concentration was significantly higher in PsA patients compared with that in HCs. The level of serum Dkk-1 was correlated with a swollen joint count, and levels of complement components 3 and 4. Elevated Dkk-1 level (odds ratio = 4.440, 95% confidence interval: 1.246–15.817, P = 0.021) was identified as the risk factor for bone erosion in PsA. Conclusions:. The serum level of Dkk-1 is abnormally elevated in PsA patients. The elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.Yukchiu ChungZhi-Chang LiXiao-Lin SunYan-Ying LiuMiao ShaoYu-Zhou GanYi-Min LiYu-Hui LiXue-Wu ZhangLi-Shao GuoWolters KluwerarticleMedicineRENChinese Medical Journal, Vol 134, Iss 21, Pp 2583-2588 (2021) |
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Medicine R Yukchiu Chung Zhi-Chang Li Xiao-Lin Sun Yan-Ying Liu Miao Shao Yu-Zhou Gan Yi-Min Li Yu-Hui Li Xue-Wu Zhang Li-Shao Guo Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| description |
Abstract. Background:. Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients.
Methods:. Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 69 patients with PsA and 60 controls, including 39 rheumatoid arthritis (RA) patients, and 21 healthy controls (HCs). Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by ELISA. The association of Dkk-1 level with clinical and laboratory features of PsA was analyzed. Logistic regression analysis was used to analyze the risk factors for bone erosion in PsA.
Results:. Dkk-1 was elevated in 68.1% (47/69) of the patients with PsA, 46.2% (18/39) of RA patients, and 9.5% (2/21) of HCs. Serum Dkk-1 concentration was significantly higher in PsA patients compared with that in HCs. The level of serum Dkk-1 was correlated with a swollen joint count, and levels of complement components 3 and 4. Elevated Dkk-1 level (odds ratio = 4.440, 95% confidence interval: 1.246–15.817, P = 0.021) was identified as the risk factor for bone erosion in PsA.
Conclusions:. The serum level of Dkk-1 is abnormally elevated in PsA patients. The elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA. |
| format |
article |
| author |
Yukchiu Chung Zhi-Chang Li Xiao-Lin Sun Yan-Ying Liu Miao Shao Yu-Zhou Gan Yi-Min Li Yu-Hui Li Xue-Wu Zhang Li-Shao Guo |
| author_facet |
Yukchiu Chung Zhi-Chang Li Xiao-Lin Sun Yan-Ying Liu Miao Shao Yu-Zhou Gan Yi-Min Li Yu-Hui Li Xue-Wu Zhang Li-Shao Guo |
| author_sort |
Yukchiu Chung |
| title |
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| title_short |
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| title_full |
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| title_fullStr |
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| title_full_unstemmed |
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| title_sort |
elevated serum dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis |
| publisher |
Wolters Kluwer |
| publishDate |
2021 |
| url |
https://doaj.org/article/be238f899fe14ba09be9ee71d0d762fd |
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