Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

Osteoarthritis (OA) is a debilitating and destructive joint disease for which disease modifying drugs are not available. Here the authors show that extracellular adenosine signalling via the A2AR receptor on chondrocytes is needed to prevent OA and that liposome-bound adenosine injection can treat t...

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Autores principales:	Carmen Corciulo, Matin Lendhey, Tuere Wilder, Hanna Schoen, Alexander Samuel Cornelissen, Gregory Chang, Oran D. Kennedy, Bruce N. Cronstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be29d18f73de4945b671857ea8466fed
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spelling	oai:doaj.org-article:be29d18f73de4945b671857ea8466fed2021-12-02T14:42:40ZEndogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression10.1038/ncomms150192041-1723https://doaj.org/article/be29d18f73de4945b671857ea8466fed2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15019https://doaj.org/toc/2041-1723Osteoarthritis (OA) is a debilitating and destructive joint disease for which disease modifying drugs are not available. Here the authors show that extracellular adenosine signalling via the A2AR receptor on chondrocytes is needed to prevent OA and that liposome-bound adenosine injection can treat the pathology in rats.Carmen CorciuloMatin LendheyTuere WilderHanna SchoenAlexander Samuel CornelissenGregory ChangOran D. KennedyBruce N. CronsteinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carmen Corciulo Matin Lendhey Tuere Wilder Hanna Schoen Alexander Samuel Cornelissen Gregory Chang Oran D. Kennedy Bruce N. Cronstein Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
description	Osteoarthritis (OA) is a debilitating and destructive joint disease for which disease modifying drugs are not available. Here the authors show that extracellular adenosine signalling via the A2AR receptor on chondrocytes is needed to prevent OA and that liposome-bound adenosine injection can treat the pathology in rats.
format	article
author	Carmen Corciulo Matin Lendhey Tuere Wilder Hanna Schoen Alexander Samuel Cornelissen Gregory Chang Oran D. Kennedy Bruce N. Cronstein
author_facet	Carmen Corciulo Matin Lendhey Tuere Wilder Hanna Schoen Alexander Samuel Cornelissen Gregory Chang Oran D. Kennedy Bruce N. Cronstein
author_sort	Carmen Corciulo
title	Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
title_short	Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
title_full	Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
title_fullStr	Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
title_full_unstemmed	Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
title_sort	endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/be29d18f73de4945b671857ea8466fed
work_keys_str_mv	AT carmencorciulo endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT matinlendhey endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT tuerewilder endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT hannaschoen endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT alexandersamuelcornelissen endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT gregorychang endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT orandkennedy endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression AT brucencronstein endogenousadenosinemaintainscartilagehomeostasisandexogenousadenosineinhibitsosteoarthritisprogression
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Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

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