Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of <named-content content-type="genus-species">Vibrio cholerae</named-content> during Coinfection with Enterotoxigenic <named-content content-type="genus-species">Escherichia coli</named-content>

Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of <named-content content-type="genus-species">Vibrio cholerae</named-content> during Coinfection with Enterotoxigenic <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models (GEMs) to explore the effect of coinfection of the diarrheagenic pathogen Vibrio choler...

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Autores principales: Alyaa M. Abdel-Haleem, Vaishnavi Ravikumar, Boyang Ji, Katsuhiko Mineta, Xin Gao, Jens Nielsen, Takashi Gojobori, Ivan Mijakovic
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
infectious diseases
cholera
diarrhea
coinfection
drug target
flux balance analysis
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/be2ba7c1adef4e90868158e2f4212684
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