Engineered ribosomes with tethered subunits for expanding biological function

Ribo-T is a tethered ribosome complex capable of orthogonal ribosome-mRNA functionality, but has low activity. Here the authors evolve new tether designs that support faster growth and increased protein expression.

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Main Authors:	Erik D. Carlson, Anne E. d’Aquino, Do Soon Kim, Emily M. Fulk, Kim Hoang, Teresa Szal, Alexander S. Mankin, Michael C. Jewett
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/be2becf5c8ec41ae9cede7fac7cd5d5c
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spelling	oai:doaj.org-article:be2becf5c8ec41ae9cede7fac7cd5d5c2021-12-02T15:35:07ZEngineered ribosomes with tethered subunits for expanding biological function10.1038/s41467-019-11427-y2041-1723https://doaj.org/article/be2becf5c8ec41ae9cede7fac7cd5d5c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11427-yhttps://doaj.org/toc/2041-1723Ribo-T is a tethered ribosome complex capable of orthogonal ribosome-mRNA functionality, but has low activity. Here the authors evolve new tether designs that support faster growth and increased protein expression.Erik D. CarlsonAnne E. d’AquinoDo Soon KimEmily M. FulkKim HoangTeresa SzalAlexander S. MankinMichael C. JewettNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik D. Carlson Anne E. d’Aquino Do Soon Kim Emily M. Fulk Kim Hoang Teresa Szal Alexander S. Mankin Michael C. Jewett Engineered ribosomes with tethered subunits for expanding biological function
description	Ribo-T is a tethered ribosome complex capable of orthogonal ribosome-mRNA functionality, but has low activity. Here the authors evolve new tether designs that support faster growth and increased protein expression.
format	article
author	Erik D. Carlson Anne E. d’Aquino Do Soon Kim Emily M. Fulk Kim Hoang Teresa Szal Alexander S. Mankin Michael C. Jewett
author_facet	Erik D. Carlson Anne E. d’Aquino Do Soon Kim Emily M. Fulk Kim Hoang Teresa Szal Alexander S. Mankin Michael C. Jewett
author_sort	Erik D. Carlson
title	Engineered ribosomes with tethered subunits for expanding biological function
title_short	Engineered ribosomes with tethered subunits for expanding biological function
title_full	Engineered ribosomes with tethered subunits for expanding biological function
title_fullStr	Engineered ribosomes with tethered subunits for expanding biological function
title_full_unstemmed	Engineered ribosomes with tethered subunits for expanding biological function
title_sort	engineered ribosomes with tethered subunits for expanding biological function
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/be2becf5c8ec41ae9cede7fac7cd5d5c
work_keys_str_mv	AT erikdcarlson engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT anneedaquino engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT dosoonkim engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT emilymfulk engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT kimhoang engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT teresaszal engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT alexandersmankin engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction AT michaelcjewett engineeredribosomeswithtetheredsubunitsforexpandingbiologicalfunction
_version_	1718386679826350080

Engineered ribosomes with tethered subunits for expanding biological function

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