Engineered ribosomes with tethered subunits for expanding biological function

Ribo-T is a tethered ribosome complex capable of orthogonal ribosome-mRNA functionality, but has low activity. Here the authors evolve new tether designs that support faster growth and increased protein expression.

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Bibliographic Details
Main Authors: Erik D. Carlson, Anne E. d’Aquino, Do Soon Kim, Emily M. Fulk, Kim Hoang, Teresa Szal, Alexander S. Mankin, Michael C. Jewett
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/be2becf5c8ec41ae9cede7fac7cd5d5c
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