COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS

Objective: To compare the efficacy of oral chloroquine with systemic meglumine antimoniate in treatment of cutaneous leishmaniasis. Study Design: Open-label comparative prospective study. Place and Duration of Study: Study was conducted in the department of Dermatology, Combined Military Hospi...

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Autores principales:	Muhammad Farooq, Muhammad Saad Farooq, Arfan Ul Bari, Tariq Mehmood Malik
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	chloroquine leishmaniasis meglumine antimoniate pentavalent antimonial Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/be2c735bf85b46989c273705b89c96dd
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spelling	oai:doaj.org-article:be2c735bf85b46989c273705b89c96dd2021-12-02T18:01:28ZCOMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS0030-96482411-884210.51253/pafmj.v71i1.3187https://doaj.org/article/be2c735bf85b46989c273705b89c96dd2021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3187https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the efficacy of oral chloroquine with systemic meglumine antimoniate in treatment of cutaneous leishmaniasis. Study Design: Open-label comparative prospective study. Place and Duration of Study: Study was conducted in the department of Dermatology, Combined Military Hospital Multan, from Jan to Oct 2018. Methodology: Fifty adult male patients completed the study. The inclusion criteria for the study were patients having untreated skin lesions less than 3 months old. Diagnosis was made on the basis of history and clinical features and was confirmed on histopathological examination. Patients were divided into 2 groups of 25 each, group A patients received meglumine antimoniate 810mg intramuscularly once a day whereas group B patients were given oral chloroquine 250mg twice a day. Pre-treatment complete physical examination was done along with blood complete picture, urine routine examination, liver function tests, renal function tests and electrocadiogram. They were repeated after 2 weeks and at the end of treatment. The efficacy was measured by healing of lesions with a measuring tape. Results: Fifty patients completed the study. At the end of treatment, among group A patients, 4 (16%) showed no improvement, 21 (84%) improved; whereas in group B patients, 11 (44%) showed no improvement, 14 (56%) showed improvement. Percentage reduction in surface area of skin lesions was 77.6% in group A, whereas in group B, it was 42.7%. Conclusion: Meglumine antimoniate showed better efficacy than chloroquine but oral chloroquine was also effective and can be used as an alternative therapy.Muhammad FarooqMuhammad Saad FarooqArfan Ul BariTariq Mehmood MalikArmy Medical College Rawalpindiarticlechloroquineleishmaniasismeglumine antimoniatepentavalent antimonialMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 139-44 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chloroquine leishmaniasis meglumine antimoniate pentavalent antimonial Medicine R Medicine (General) R5-920
spellingShingle	chloroquine leishmaniasis meglumine antimoniate pentavalent antimonial Medicine R Medicine (General) R5-920 Muhammad Farooq Muhammad Saad Farooq Arfan Ul Bari Tariq Mehmood Malik COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
description	Objective: To compare the efficacy of oral chloroquine with systemic meglumine antimoniate in treatment of cutaneous leishmaniasis. Study Design: Open-label comparative prospective study. Place and Duration of Study: Study was conducted in the department of Dermatology, Combined Military Hospital Multan, from Jan to Oct 2018. Methodology: Fifty adult male patients completed the study. The inclusion criteria for the study were patients having untreated skin lesions less than 3 months old. Diagnosis was made on the basis of history and clinical features and was confirmed on histopathological examination. Patients were divided into 2 groups of 25 each, group A patients received meglumine antimoniate 810mg intramuscularly once a day whereas group B patients were given oral chloroquine 250mg twice a day. Pre-treatment complete physical examination was done along with blood complete picture, urine routine examination, liver function tests, renal function tests and electrocadiogram. They were repeated after 2 weeks and at the end of treatment. The efficacy was measured by healing of lesions with a measuring tape. Results: Fifty patients completed the study. At the end of treatment, among group A patients, 4 (16%) showed no improvement, 21 (84%) improved; whereas in group B patients, 11 (44%) showed no improvement, 14 (56%) showed improvement. Percentage reduction in surface area of skin lesions was 77.6% in group A, whereas in group B, it was 42.7%. Conclusion: Meglumine antimoniate showed better efficacy than chloroquine but oral chloroquine was also effective and can be used as an alternative therapy.
format	article
author	Muhammad Farooq Muhammad Saad Farooq Arfan Ul Bari Tariq Mehmood Malik
author_facet	Muhammad Farooq Muhammad Saad Farooq Arfan Ul Bari Tariq Mehmood Malik
author_sort	Muhammad Farooq
title	COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
title_short	COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
title_full	COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
title_fullStr	COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
title_full_unstemmed	COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS
title_sort	comparison of oral chloroquine with systemic meglumine antimoniate in treatment of cutaneous leishmaniasis
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/be2c735bf85b46989c273705b89c96dd
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COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS

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