Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied...

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Autores principales:	Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ikeda R, Ando T, Oshita H, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, Akiyoshi J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/be2ca669af7f400bb52447a7917c5243
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spelling	oai:doaj.org-article:be2ca669af7f400bb52447a7917c52432021-12-02T02:19:41ZAssociation of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress1178-2021https://doaj.org/article/be2ca669af7f400bb52447a7917c52432014-11-01T00:00:00Zhttp://www.dovepress.com/association-of-bdnf-val66met-polymorphism-with-hpa-and-sam-axis-reacti-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A).Results: A significant three-way interaction (time [3 levels] × BDNF [Val/Val, Val/Met, Met/Met]; P<0.05) was demonstrated that revealed different salivary cortisol responses in the TSST but not in electrical stimulation. Met/Met women had stronger cortisol responses than Val/Met and Val/Val individuals in the TSST. Met/Met men exhibited stronger salivary cortisol responses than Val/Met and Val/Val individuals in the TSST.Conclusion: These results indicate that a common, functionally significant polymorphism in BDNF had different effects on hypothalamic–pituitary–adrenocortical axis reactivity but not on sympathetic adrenomedullary reactivity in TSST and electrical stimulation tests. Keywords: stress, brain-derived neurotrophic factor, cortisol, salivaTsuru JTanaka YIshitobi YMaruyama YInoue AKawano AIkeda RAndo TOshita HAizawa SMasuda KHiguma HKanehisa MNinomiya TAkiyoshi JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2123-2133 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tsuru J Tanaka Y Ishitobi Y Maruyama Y Inoue A Kawano A Ikeda R Ando T Oshita H Aizawa S Masuda K Higuma H Kanehisa M Ninomiya T Akiyoshi J Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
description	Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A).Results: A significant three-way interaction (time [3 levels] × BDNF [Val/Val, Val/Met, Met/Met]; P<0.05) was demonstrated that revealed different salivary cortisol responses in the TSST but not in electrical stimulation. Met/Met women had stronger cortisol responses than Val/Met and Val/Val individuals in the TSST. Met/Met men exhibited stronger salivary cortisol responses than Val/Met and Val/Val individuals in the TSST.Conclusion: These results indicate that a common, functionally significant polymorphism in BDNF had different effects on hypothalamic–pituitary–adrenocortical axis reactivity but not on sympathetic adrenomedullary reactivity in TSST and electrical stimulation tests. Keywords: stress, brain-derived neurotrophic factor, cortisol, saliva
format	article
author	Tsuru J Tanaka Y Ishitobi Y Maruyama Y Inoue A Kawano A Ikeda R Ando T Oshita H Aizawa S Masuda K Higuma H Kanehisa M Ninomiya T Akiyoshi J
author_facet	Tsuru J Tanaka Y Ishitobi Y Maruyama Y Inoue A Kawano A Ikeda R Ando T Oshita H Aizawa S Masuda K Higuma H Kanehisa M Ninomiya T Akiyoshi J
author_sort	Tsuru J
title	Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
title_short	Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
title_full	Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
title_fullStr	Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
title_full_unstemmed	Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
title_sort	association of bdnf val66met polymorphism with hpa and sam axis reactivity to psychological and physical stress
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/be2ca669af7f400bb52447a7917c5243
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Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

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