Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

CRISPR activation strategies in bacteria are limited due to the reliance on σ70 promoters. Here the authors demonstrate eukaryote-like gene activation with high dynamic ranges using σ54- dependent promoters.

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Detalles Bibliográficos
Autores principales:	Yang Liu, Xinyi Wan, Baojun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be2d208189814f2a9238de4dcea1a921
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spelling	oai:doaj.org-article:be2d208189814f2a9238de4dcea1a9212021-12-02T14:39:17ZEngineered CRISPRa enables programmable eukaryote-like gene activation in bacteria10.1038/s41467-019-11479-02041-1723https://doaj.org/article/be2d208189814f2a9238de4dcea1a9212019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11479-0https://doaj.org/toc/2041-1723CRISPR activation strategies in bacteria are limited due to the reliance on σ70 promoters. Here the authors demonstrate eukaryote-like gene activation with high dynamic ranges using σ54- dependent promoters.Yang LiuXinyi WanBaojun WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Liu Xinyi Wan Baojun Wang Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
description	CRISPR activation strategies in bacteria are limited due to the reliance on σ70 promoters. Here the authors demonstrate eukaryote-like gene activation with high dynamic ranges using σ54- dependent promoters.
format	article
author	Yang Liu Xinyi Wan Baojun Wang
author_facet	Yang Liu Xinyi Wan Baojun Wang
author_sort	Yang Liu
title	Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
title_short	Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
title_full	Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
title_fullStr	Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
title_full_unstemmed	Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
title_sort	engineered crispra enables programmable eukaryote-like gene activation in bacteria
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/be2d208189814f2a9238de4dcea1a921
work_keys_str_mv	AT yangliu engineeredcrispraenablesprogrammableeukaryotelikegeneactivationinbacteria AT xinyiwan engineeredcrispraenablesprogrammableeukaryotelikegeneactivationinbacteria AT baojunwang engineeredcrispraenablesprogrammableeukaryotelikegeneactivationinbacteria
_version_	1718390678561488896

Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

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