Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation

Abstract Immune class in hepatocellular carcinoma (HCC) has been shown to possess immunogenic power; however, how preestablished immune landscapes in premalignant and early HCC stages impact the clinical outcomes of HCC patients remains unexplored. We sequenced bulk transcriptomes for 62 malignant t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sang-Ho Yoon, Seo-Won Choi, Suk Woo Nam, Kyoung Bun Lee, Jin-Wu Nam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/be2d57dbb8d94979ae11c1777d38e809
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:be2d57dbb8d94979ae11c1777d38e809
record_format	dspace
spelling	oai:doaj.org-article:be2d57dbb8d94979ae11c1777d38e8092021-12-02T13:24:00ZPreoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation10.1038/s41698-021-00167-22397-768Xhttps://doaj.org/article/be2d57dbb8d94979ae11c1777d38e8092021-03-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00167-2https://doaj.org/toc/2397-768XAbstract Immune class in hepatocellular carcinoma (HCC) has been shown to possess immunogenic power; however, how preestablished immune landscapes in premalignant and early HCC stages impact the clinical outcomes of HCC patients remains unexplored. We sequenced bulk transcriptomes for 62 malignant tumor samples from a Korean HCC cohort in which 38 patients underwent total hepatectomy, as well as for 15 normal and 47 adjacent nontumor samples. Using in silico deconvolution of expression mixtures, 22 immune cell fractions for each sample were inferred, and validated with immune cell counting by immunohistochemistry. Cell type-specific immune signatures dynamically shifted from premalignant stages to the late HCC stage. Total hepatectomy patients displayed elevated immune infiltration and prolonged disease-free survival compared to the partial hepatectomy patients. However, patients who exhibited an infiltration of regulatory T cells (Tregs) during the pretransplantation period displayed a high risk of tumor relapse with suppressed immune responses, and pretreatment was a potential driver of Treg infiltration in the total hepatectomy group. Treg infiltration appeared to be independent of molecular classifications based on transcriptomic data. Our study provides not only comprehensive immune signatures in adjacent nontumor lesions and early malignant HCC stages but also clinical guidance for HCC patients who will undergo liver transplantation.Sang-Ho YoonSeo-Won ChoiSuk Woo NamKyoung Bun LeeJin-Wu NamNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sang-Ho Yoon Seo-Won Choi Suk Woo Nam Kyoung Bun Lee Jin-Wu Nam Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
description	Abstract Immune class in hepatocellular carcinoma (HCC) has been shown to possess immunogenic power; however, how preestablished immune landscapes in premalignant and early HCC stages impact the clinical outcomes of HCC patients remains unexplored. We sequenced bulk transcriptomes for 62 malignant tumor samples from a Korean HCC cohort in which 38 patients underwent total hepatectomy, as well as for 15 normal and 47 adjacent nontumor samples. Using in silico deconvolution of expression mixtures, 22 immune cell fractions for each sample were inferred, and validated with immune cell counting by immunohistochemistry. Cell type-specific immune signatures dynamically shifted from premalignant stages to the late HCC stage. Total hepatectomy patients displayed elevated immune infiltration and prolonged disease-free survival compared to the partial hepatectomy patients. However, patients who exhibited an infiltration of regulatory T cells (Tregs) during the pretransplantation period displayed a high risk of tumor relapse with suppressed immune responses, and pretreatment was a potential driver of Treg infiltration in the total hepatectomy group. Treg infiltration appeared to be independent of molecular classifications based on transcriptomic data. Our study provides not only comprehensive immune signatures in adjacent nontumor lesions and early malignant HCC stages but also clinical guidance for HCC patients who will undergo liver transplantation.
format	article
author	Sang-Ho Yoon Seo-Won Choi Suk Woo Nam Kyoung Bun Lee Jin-Wu Nam
author_facet	Sang-Ho Yoon Seo-Won Choi Suk Woo Nam Kyoung Bun Lee Jin-Wu Nam
author_sort	Sang-Ho Yoon
title	Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
title_short	Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
title_full	Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
title_fullStr	Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
title_full_unstemmed	Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
title_sort	preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be2d57dbb8d94979ae11c1777d38e809
work_keys_str_mv	AT sanghoyoon preoperativeimmunelandscapepredisposesadverseoutcomesinhepatocellularcarcinomapatientswithlivertransplantation AT seowonchoi preoperativeimmunelandscapepredisposesadverseoutcomesinhepatocellularcarcinomapatientswithlivertransplantation AT sukwoonam preoperativeimmunelandscapepredisposesadverseoutcomesinhepatocellularcarcinomapatientswithlivertransplantation AT kyoungbunlee preoperativeimmunelandscapepredisposesadverseoutcomesinhepatocellularcarcinomapatientswithlivertransplantation AT jinwunam preoperativeimmunelandscapepredisposesadverseoutcomesinhepatocellularcarcinomapatientswithlivertransplantation
_version_	1718393178148569088

Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation

Ejemplares similares