Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese

Abstract TOLLIP polymorphism has been implicated in the development and prognosis of idiopathic pulmonary fibrosis (IPF), mainly in whites. However, ethnic differences in the characteristics of other interstitial pneumonia (non-IPF) subtypes are unclear. We evaluated the association between the rs37...

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Autores principales:	Takuma Isshiki, Kazuya Koyama, Sakae Homma, Susumu Sakamoto, Akira Yamasaki, Hiroshige Shimizu, Shion Miyoshi, Yasuhiko Nakamura, Kazuma Kishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be2e0b01024042e48bc9da9e0eee92ae
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spelling	oai:doaj.org-article:be2e0b01024042e48bc9da9e0eee92ae2021-12-02T16:43:42ZAssociation of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese10.1038/s41598-021-95869-92045-2322https://doaj.org/article/be2e0b01024042e48bc9da9e0eee92ae2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95869-9https://doaj.org/toc/2045-2322Abstract TOLLIP polymorphism has been implicated in the development and prognosis of idiopathic pulmonary fibrosis (IPF), mainly in whites. However, ethnic differences in the characteristics of other interstitial pneumonia (non-IPF) subtypes are unclear. We evaluated the association between the rs3750920 genotype and the clinical characteristics of Japanese patients with fibrosing interstitial lung diseases (ILD). We genotyped 102 patients with fibrosing ILD (75 IPF and 27 non-IPF patients) and analyzed the interaction between the rs3750920 genotype distribution and their clinical characteristics. The overall frequencies of the C/C, C/T, and T/T genotypes were 69%, 25%, and 6%, respectively. The proportion of minor T allele carriers was larger in IPF patients than in non-IPF patients (37% vs. 15%, P = 0.031). In addition, survival at 3 years was significantly better for carriers than for non-carriers of the T allele. There was no significant association between genotype distribution and change in pulmonary function after introduction of antifibrotic agents. The frequency of the minor T allele of rs3750920 was low in Japanese patients with fibrosing ILD, particularly in non-IPF patients. Carriers of the minor T allele had better survival than non-carriers. Presence of the T allele might thus be an indicator of better outcomes for fibrosing ILD.Takuma IsshikiKazuya KoyamaSakae HommaSusumu SakamotoAkira YamasakiHiroshige ShimizuShion MiyoshiYasuhiko NakamuraKazuma KishiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takuma Isshiki Kazuya Koyama Sakae Homma Susumu Sakamoto Akira Yamasaki Hiroshige Shimizu Shion Miyoshi Yasuhiko Nakamura Kazuma Kishi Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
description	Abstract TOLLIP polymorphism has been implicated in the development and prognosis of idiopathic pulmonary fibrosis (IPF), mainly in whites. However, ethnic differences in the characteristics of other interstitial pneumonia (non-IPF) subtypes are unclear. We evaluated the association between the rs3750920 genotype and the clinical characteristics of Japanese patients with fibrosing interstitial lung diseases (ILD). We genotyped 102 patients with fibrosing ILD (75 IPF and 27 non-IPF patients) and analyzed the interaction between the rs3750920 genotype distribution and their clinical characteristics. The overall frequencies of the C/C, C/T, and T/T genotypes were 69%, 25%, and 6%, respectively. The proportion of minor T allele carriers was larger in IPF patients than in non-IPF patients (37% vs. 15%, P = 0.031). In addition, survival at 3 years was significantly better for carriers than for non-carriers of the T allele. There was no significant association between genotype distribution and change in pulmonary function after introduction of antifibrotic agents. The frequency of the minor T allele of rs3750920 was low in Japanese patients with fibrosing ILD, particularly in non-IPF patients. Carriers of the minor T allele had better survival than non-carriers. Presence of the T allele might thus be an indicator of better outcomes for fibrosing ILD.
format	article
author	Takuma Isshiki Kazuya Koyama Sakae Homma Susumu Sakamoto Akira Yamasaki Hiroshige Shimizu Shion Miyoshi Yasuhiko Nakamura Kazuma Kishi
author_facet	Takuma Isshiki Kazuya Koyama Sakae Homma Susumu Sakamoto Akira Yamasaki Hiroshige Shimizu Shion Miyoshi Yasuhiko Nakamura Kazuma Kishi
author_sort	Takuma Isshiki
title	Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
title_short	Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
title_full	Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
title_fullStr	Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
title_full_unstemmed	Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese
title_sort	association of rs3750920 polymorphism in tollip with clinical characteristics of fibrosing interstitial lung diseases in japanese
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be2e0b01024042e48bc9da9e0eee92ae
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Association of rs3750920 polymorphism in TOLLIP with clinical characteristics of fibrosing interstitial lung diseases in Japanese

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