North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up.
<h4>Introduction</h4>The aim of this study was to report 36-month longitudinal changes using the North Star Ambulatory Assessment (NSAA) in ambulant patients affected by Duchenne muscular dystrophy amenable to skip exons 44, 45, 51 or 53.<h4>Materials and methods</h4>We inclu...
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oai:doaj.org-article:be2f7562560244a9a2a56400fc1fd6e82021-12-02T20:09:56ZNorth Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up.1932-620310.1371/journal.pone.0253882https://doaj.org/article/be2f7562560244a9a2a56400fc1fd6e82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253882https://doaj.org/toc/1932-6203<h4>Introduction</h4>The aim of this study was to report 36-month longitudinal changes using the North Star Ambulatory Assessment (NSAA) in ambulant patients affected by Duchenne muscular dystrophy amenable to skip exons 44, 45, 51 or 53.<h4>Materials and methods</h4>We included 101 patients, 34 had deletions amenable to skip exon 44, 25 exon 45, 19 exon 51, and 28 exon 53, not recruited in any ongoing clinical trials. Five patients were counted to skip exon 51 and 53 since they had a single deletion of exon 52.<h4>Results</h4>The difference between subgroups (skip 44, 45, 51 and 53) was significant at 12 (p = 0.043), 24 (p = 0.005) and 36 months (p≤0.001).<h4>Discussion</h4>Mutations amenable to skip exons 53 and 51 had lower baseline values and more negative changes than the other subgroups while those amenable to skip exon 44 had higher scores both at baseline and at follow up.<h4>Conclusion</h4>Our results confirm different progression of disease in subgroups of patients with deletions amenable to skip different exons. This information is relevant as current long term clinical trials are using the NSAA in these subgroups of mutations.Giorgia CorattiMarika PaneClaudia BrognaValeria RicottiSonia MessinaAdele D'AmicoClaudio BrunoGianluca VitaAngela BerardinelliElena MazzoneFrancesca MagriFederica RicciTiziana MonginiRoberta BattiniLuca BelloElena PegoraroGiovanni BaranelloStefano C PrevitaliLuisa PolitanoGiacomo P ComiValeria A SansoneAlice DonatiJean Yves HogrelVolker StraubSilvana De LuciaErik NiksLaurent ServaisImelda De GrootMary ChesshyreEnrico BertiniNathalie GoemansFrancesco MuntoniEugenio Mercurion behalf on the International DMD Group and the iMDEX ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253882 (2021) |
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Medicine R Science Q Giorgia Coratti Marika Pane Claudia Brogna Valeria Ricotti Sonia Messina Adele D'Amico Claudio Bruno Gianluca Vita Angela Berardinelli Elena Mazzone Francesca Magri Federica Ricci Tiziana Mongini Roberta Battini Luca Bello Elena Pegoraro Giovanni Baranello Stefano C Previtali Luisa Politano Giacomo P Comi Valeria A Sansone Alice Donati Jean Yves Hogrel Volker Straub Silvana De Lucia Erik Niks Laurent Servais Imelda De Groot Mary Chesshyre Enrico Bertini Nathalie Goemans Francesco Muntoni Eugenio Mercuri on behalf on the International DMD Group and the iMDEX Consortium North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| description |
<h4>Introduction</h4>The aim of this study was to report 36-month longitudinal changes using the North Star Ambulatory Assessment (NSAA) in ambulant patients affected by Duchenne muscular dystrophy amenable to skip exons 44, 45, 51 or 53.<h4>Materials and methods</h4>We included 101 patients, 34 had deletions amenable to skip exon 44, 25 exon 45, 19 exon 51, and 28 exon 53, not recruited in any ongoing clinical trials. Five patients were counted to skip exon 51 and 53 since they had a single deletion of exon 52.<h4>Results</h4>The difference between subgroups (skip 44, 45, 51 and 53) was significant at 12 (p = 0.043), 24 (p = 0.005) and 36 months (p≤0.001).<h4>Discussion</h4>Mutations amenable to skip exons 53 and 51 had lower baseline values and more negative changes than the other subgroups while those amenable to skip exon 44 had higher scores both at baseline and at follow up.<h4>Conclusion</h4>Our results confirm different progression of disease in subgroups of patients with deletions amenable to skip different exons. This information is relevant as current long term clinical trials are using the NSAA in these subgroups of mutations. |
| format |
article |
| author |
Giorgia Coratti Marika Pane Claudia Brogna Valeria Ricotti Sonia Messina Adele D'Amico Claudio Bruno Gianluca Vita Angela Berardinelli Elena Mazzone Francesca Magri Federica Ricci Tiziana Mongini Roberta Battini Luca Bello Elena Pegoraro Giovanni Baranello Stefano C Previtali Luisa Politano Giacomo P Comi Valeria A Sansone Alice Donati Jean Yves Hogrel Volker Straub Silvana De Lucia Erik Niks Laurent Servais Imelda De Groot Mary Chesshyre Enrico Bertini Nathalie Goemans Francesco Muntoni Eugenio Mercuri on behalf on the International DMD Group and the iMDEX Consortium |
| author_facet |
Giorgia Coratti Marika Pane Claudia Brogna Valeria Ricotti Sonia Messina Adele D'Amico Claudio Bruno Gianluca Vita Angela Berardinelli Elena Mazzone Francesca Magri Federica Ricci Tiziana Mongini Roberta Battini Luca Bello Elena Pegoraro Giovanni Baranello Stefano C Previtali Luisa Politano Giacomo P Comi Valeria A Sansone Alice Donati Jean Yves Hogrel Volker Straub Silvana De Lucia Erik Niks Laurent Servais Imelda De Groot Mary Chesshyre Enrico Bertini Nathalie Goemans Francesco Muntoni Eugenio Mercuri on behalf on the International DMD Group and the iMDEX Consortium |
| author_sort |
Giorgia Coratti |
| title |
North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| title_short |
North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| title_full |
North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| title_fullStr |
North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| title_full_unstemmed |
North Star Ambulatory Assessment changes in ambulant Duchenne boys amenable to skip exons 44, 45, 51, and 53: A 3 year follow up. |
| title_sort |
north star ambulatory assessment changes in ambulant duchenne boys amenable to skip exons 44, 45, 51, and 53: a 3 year follow up. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/be2f7562560244a9a2a56400fc1fd6e8 |
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