Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System

Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of th...

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Autores principales:	Carolina Amado, Valter Duarte, Mariana Silva Leal, Margarida Cruz, Gisela Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	chronic lymphocytic leukaemia central nervous system Medicine R
Acceso en línea:	https://doaj.org/article/be33cb8557e540b1baa9d48cb9cf8ebe
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spelling	oai:doaj.org-article:be33cb8557e540b1baa9d48cb9cf8ebe2021-11-09T11:22:42ZChronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System2284-259410.12890/2021_002847https://doaj.org/article/be33cb8557e540b1baa9d48cb9cf8ebe2021-11-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2847https://doaj.org/toc/2284-2594Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging. The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards.Carolina AmadoValter DuarteMariana Silva LealMargarida CruzGisela FerreiraSMC MEDIA SRLarticlechronic lymphocytic leukaemiacentral nervous systemMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic lymphocytic leukaemia central nervous system Medicine R
spellingShingle	chronic lymphocytic leukaemia central nervous system Medicine R Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
description	Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging. The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards.
format	article
author	Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira
author_facet	Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira
author_sort	Carolina Amado
title	Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
title_short	Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
title_full	Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
title_fullStr	Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
title_full_unstemmed	Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
title_sort	chronic lymphocytic leukaemia: rare involvement of the central nervous system
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/be33cb8557e540b1baa9d48cb9cf8ebe
work_keys_str_mv	AT carolinaamado chroniclymphocyticleukaemiarareinvolvementofthecentralnervoussystem AT valterduarte chroniclymphocyticleukaemiarareinvolvementofthecentralnervoussystem AT marianasilvaleal chroniclymphocyticleukaemiarareinvolvementofthecentralnervoussystem AT margaridacruz chroniclymphocyticleukaemiarareinvolvementofthecentralnervoussystem AT giselaferreira chroniclymphocyticleukaemiarareinvolvementofthecentralnervoussystem
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Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System

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