Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)

This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. V. Semenova, I. M. Madaeva, L. I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	oxidative stress carbonyl stress sleep disorders andropause menopause Science Q
Acceso en línea:	https://doaj.org/article/be3a556d4eb248ac9fd1c9b7939044d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:be3a556d4eb248ac9fd1c9b7939044d3
record_format	dspace
spelling	oai:doaj.org-article:be3a556d4eb248ac9fd1c9b7939044d32021-11-23T06:14:43ZFree Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)2541-94202587-959610.29413/ABS.2020-5.1.4https://doaj.org/article/be3a556d4eb248ac9fd1c9b7939044d32020-03-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2236https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation in animal models are presented, indicating the dependence of processes on the duration of sleep deprivation. The largest number of studies of free radical processes in a person with somnological pathology was carried out in the study of OSAS. Blood, urine, saliva, condensate of exhaled air can be biomaterial for determining the parameters of free radical oxidation. It was shown that the intensity of oxidative stress depends on the severity of OSAS, as evidenced by the positive correlation of the level of active products of thiobarbituric acid, the products of oxidation of proteins and carbonyl groups with the apnea/hypopnea index, determining the development of not only oxidative, but also carbonyl stress in patients with a severe degree OSAS. Biomarkers such as thioredoxin, malondialdehyde, superoxide dismutase, and reduced iron have shown a more stable relationship between increased oxidative stress and OSA. Despite the results obtained, the question of the association of oxidative stress and hypoxia in OSA remains debatable, which is associated with the opposite results of some studies. Insomnia, which occurs mainly in females, is accompanied by a high level of end products of lipid peroxidation with a decrease in the activity of antioxidants such as paraoxonase, an enzymatic component of the glutathione system. Along with this, menopausal women present low levels of uric acid, which correlates with high scores of the Pittsburgh sleep quality index questionnaire. Recent studies have identified an association between the activity of the «lipoperoxidation – antioxidants» system and the Clock 3111T/C gene polymorphism in menopausal Caucasian women, indicating the protective role of the minor allele.N. V. SemenovaI. M. MadaevaL. I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticleoxidative stresscarbonyl stresssleep disordersandropausemenopauseScienceQRUActa Biomedica Scientifica, Vol 5, Iss 1, Pp 31-41 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	oxidative stress carbonyl stress sleep disorders andropause menopause Science Q
spellingShingle	oxidative stress carbonyl stress sleep disorders andropause menopause Science Q N. V. Semenova I. M. Madaeva L. I. Kolesnikova Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
description	This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation in animal models are presented, indicating the dependence of processes on the duration of sleep deprivation. The largest number of studies of free radical processes in a person with somnological pathology was carried out in the study of OSAS. Blood, urine, saliva, condensate of exhaled air can be biomaterial for determining the parameters of free radical oxidation. It was shown that the intensity of oxidative stress depends on the severity of OSAS, as evidenced by the positive correlation of the level of active products of thiobarbituric acid, the products of oxidation of proteins and carbonyl groups with the apnea/hypopnea index, determining the development of not only oxidative, but also carbonyl stress in patients with a severe degree OSAS. Biomarkers such as thioredoxin, malondialdehyde, superoxide dismutase, and reduced iron have shown a more stable relationship between increased oxidative stress and OSA. Despite the results obtained, the question of the association of oxidative stress and hypoxia in OSA remains debatable, which is associated with the opposite results of some studies. Insomnia, which occurs mainly in females, is accompanied by a high level of end products of lipid peroxidation with a decrease in the activity of antioxidants such as paraoxonase, an enzymatic component of the glutathione system. Along with this, menopausal women present low levels of uric acid, which correlates with high scores of the Pittsburgh sleep quality index questionnaire. Recent studies have identified an association between the activity of the «lipoperoxidation – antioxidants» system and the Clock 3111T/C gene polymorphism in menopausal Caucasian women, indicating the protective role of the minor allele.
format	article
author	N. V. Semenova I. M. Madaeva L. I. Kolesnikova
author_facet	N. V. Semenova I. M. Madaeva L. I. Kolesnikova
author_sort	N. V. Semenova
title	Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
title_short	Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
title_full	Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
title_fullStr	Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
title_full_unstemmed	Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)
title_sort	free radical oxidation and sleep disorders in andro- and menopause (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/be3a556d4eb248ac9fd1c9b7939044d3
work_keys_str_mv	AT nvsemenova freeradicaloxidationandsleepdisordersinandroandmenopauseliteraturereview AT immadaeva freeradicaloxidationandsleepdisordersinandroandmenopauseliteraturereview AT likolesnikova freeradicaloxidationandsleepdisordersinandroandmenopauseliteraturereview
_version_	1718416904656257024

Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)

Ejemplares similares