Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid

Aim. To evaluate effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid. Materials and methods. This work is a prospective open randomized comparative clinical study including 4 parallel groups of patients. Group 1(n=31) comprised pa...

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Autores principales:	Vladimir Nikolaevich Khramilin, Irina Yur'evna Demidova, Olga Yur'evna Ignatova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	painful diabetic polyneuropathy diabetes mellitus lipoic acid Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/be3f258403c348a89959a502d12f1272
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spelling	oai:doaj.org-article:be3f258403c348a89959a502d12f12722021-11-14T09:00:15ZEvaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid2072-03512072-037810.14341/2072-0351-5670https://doaj.org/article/be3f258403c348a89959a502d12f12722010-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5670https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid. Materials and methods. This work is a prospective open randomized comparative clinical study including 4 parallel groups of patients. Group 1(n=31) comprised patients given 600 mg ALA daily (two 300 mg tablets at a time), group 2 (n=28) 600 mg ALA daily (two 300 mg tablets in succession),group 3 (n=35) 900 mg ALA daily (three 300 mg tablets at a time in the morning), group 4 (n=27) 900 mg ALA daily (three 300 mg tablets in succession30-40 min before meals). Active treatment lasted 3 months. Results. Beneficial effect of 3 ALA tablets on neurologic symptoms estimated by NTSS-6 and 9 scales was significantly more pronounced than that oftwo 300 mg tablets taken either once or twice a day. The groups were analysed in terms of the number of patients who achieved or failed to achievethe end point of therapy (responders, n=86 and non-responders, n=29). The HbA1c level and the degree of sensory deficit were shown to begood predictors of therapeutic efficiency. There was moderate correlation between HbA1c level (>8%), NIS LL and NIS LL-sensory function points,and frequency of response to ALA therapy (r=0.251; p=0.007 // r=0.32; p=0.00077 // r=0.32; p=0.0015 respectively). Patients having HbA1c8.0%) and severedisturbances of sensory function (e.g. monofilament resistance) may be used as predictors of therapeutic efficiency.Vladimir Nikolaevich KhramilinIrina Yur'evna DemidovaOlga Yur'evna IgnatovaEndocrinology Research Centrearticlepainful diabetic polyneuropathydiabetes mellituslipoic acidNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 2, Pp 28-32 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	painful diabetic polyneuropathy diabetes mellitus lipoic acid Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	painful diabetic polyneuropathy diabetes mellitus lipoic acid Nutritional diseases. Deficiency diseases RC620-627 Vladimir Nikolaevich Khramilin Irina Yur'evna Demidova Olga Yur'evna Ignatova Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
description	Aim. To evaluate effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid. Materials and methods. This work is a prospective open randomized comparative clinical study including 4 parallel groups of patients. Group 1(n=31) comprised patients given 600 mg ALA daily (two 300 mg tablets at a time), group 2 (n=28) 600 mg ALA daily (two 300 mg tablets in succession),group 3 (n=35) 900 mg ALA daily (three 300 mg tablets at a time in the morning), group 4 (n=27) 900 mg ALA daily (three 300 mg tablets in succession30-40 min before meals). Active treatment lasted 3 months. Results. Beneficial effect of 3 ALA tablets on neurologic symptoms estimated by NTSS-6 and 9 scales was significantly more pronounced than that oftwo 300 mg tablets taken either once or twice a day. The groups were analysed in terms of the number of patients who achieved or failed to achievethe end point of therapy (responders, n=86 and non-responders, n=29). The HbA1c level and the degree of sensory deficit were shown to begood predictors of therapeutic efficiency. There was moderate correlation between HbA1c level (>8%), NIS LL and NIS LL-sensory function points,and frequency of response to ALA therapy (r=0.251; p=0.007 // r=0.32; p=0.00077 // r=0.32; p=0.0015 respectively). Patients having HbA1c8.0%) and severedisturbances of sensory function (e.g. monofilament resistance) may be used as predictors of therapeutic efficiency.
format	article
author	Vladimir Nikolaevich Khramilin Irina Yur'evna Demidova Olga Yur'evna Ignatova
author_facet	Vladimir Nikolaevich Khramilin Irina Yur'evna Demidova Olga Yur'evna Ignatova
author_sort	Vladimir Nikolaevich Khramilin
title	Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
title_short	Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
title_full	Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
title_fullStr	Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
title_full_unstemmed	Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
title_sort	evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/be3f258403c348a89959a502d12f1272
work_keys_str_mv	AT vladimirnikolaevichkhramilin evaluationofeffectivenessofdifferentmodesofperostherapyofpainfuldiabeticperipheralpolyneuropathywithalphalipoicacid AT irinayurevnademidova evaluationofeffectivenessofdifferentmodesofperostherapyofpainfuldiabeticperipheralpolyneuropathywithalphalipoicacid AT olgayurevnaignatova evaluationofeffectivenessofdifferentmodesofperostherapyofpainfuldiabeticperipheralpolyneuropathywithalphalipoicacid
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Evaluation of effectiveness of different modes of per os therapy of painful diabetic peripheral polyneuropathy with alpha-lipoic acid

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