The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase
Aging is a natural process with concomitant changes in the gut microbiota and associate metabolomes. Beta-nicotinamide mononucleotide, an important NAD+ intermediate, has drawn increasing attention to retard the aging process. We probed the changes in the fecal microbiota and metabolomes of pre-agin...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:be3fd8bacc5c472e85bb1e5bd63b62d02021-12-01T14:04:56ZThe Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase2296-861X10.3389/fnut.2021.756243https://doaj.org/article/be3fd8bacc5c472e85bb1e5bd63b62d02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.756243/fullhttps://doaj.org/toc/2296-861XAging is a natural process with concomitant changes in the gut microbiota and associate metabolomes. Beta-nicotinamide mononucleotide, an important NAD+ intermediate, has drawn increasing attention to retard the aging process. We probed the changes in the fecal microbiota and metabolomes of pre-aging male mice (C57BL/6, age: 16 months) following the oral short-term administration of nicotinamide mononucleotide (NMN). Considering the telomere length as a molecular gauge for aging, we measured this in the peripheral blood mononuclear cells (PBMC) of pre-aging mice and human volunteers (age: 45–60 years old). Notably, the NMN administration did not influence the body weight and feed intake significantly during the 40 days in pre-aging mice. Metabolomics suggested 266 upregulated and 58 downregulated serum metabolites. We identified 34 potential biomarkers linked with the nicotinamide, purine, and proline metabolism pathways. Nicotinamide mononucleotide significantly reduced the fecal bacterial diversity (p < 0.05) with the increased abundance of Helicobacter, Mucispirillum, and Faecalibacterium, and lowered Akkermansia abundance associated with nicotinamide metabolism. We propose that this reshaped microbiota considerably lowered the predicated functions of aging with improved immune and cofactors/vitamin metabolism. Most notably, the telomere length of PBMC was significantly elongated in the NMN-administered mice and humans. Taken together, these findings suggest that oral NMN supplementation in the pre-aging stage might be an effective strategy to retard aging. We recommend further studies to unravel the underlying molecular mechanisms and comprehensive clinical trials to validate the effects of NMN on aging.Kai-Min NiuKai-Min NiuKai-Min NiuTongtong BaoTongtong BaoLumin GaoMeng RuYumeng LiLiang JiangChangming YeShujin WangShujin WangXin WuXin WuXin WuFrontiers Media S.A.articleNMNtelomerepre-agingmicrobiotametabolomicNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021) |
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NMN telomere pre-aging microbiota metabolomic Nutrition. Foods and food supply TX341-641 |
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NMN telomere pre-aging microbiota metabolomic Nutrition. Foods and food supply TX341-641 Kai-Min Niu Kai-Min Niu Kai-Min Niu Tongtong Bao Tongtong Bao Lumin Gao Meng Ru Yumeng Li Liang Jiang Changming Ye Shujin Wang Shujin Wang Xin Wu Xin Wu Xin Wu The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| description |
Aging is a natural process with concomitant changes in the gut microbiota and associate metabolomes. Beta-nicotinamide mononucleotide, an important NAD+ intermediate, has drawn increasing attention to retard the aging process. We probed the changes in the fecal microbiota and metabolomes of pre-aging male mice (C57BL/6, age: 16 months) following the oral short-term administration of nicotinamide mononucleotide (NMN). Considering the telomere length as a molecular gauge for aging, we measured this in the peripheral blood mononuclear cells (PBMC) of pre-aging mice and human volunteers (age: 45–60 years old). Notably, the NMN administration did not influence the body weight and feed intake significantly during the 40 days in pre-aging mice. Metabolomics suggested 266 upregulated and 58 downregulated serum metabolites. We identified 34 potential biomarkers linked with the nicotinamide, purine, and proline metabolism pathways. Nicotinamide mononucleotide significantly reduced the fecal bacterial diversity (p < 0.05) with the increased abundance of Helicobacter, Mucispirillum, and Faecalibacterium, and lowered Akkermansia abundance associated with nicotinamide metabolism. We propose that this reshaped microbiota considerably lowered the predicated functions of aging with improved immune and cofactors/vitamin metabolism. Most notably, the telomere length of PBMC was significantly elongated in the NMN-administered mice and humans. Taken together, these findings suggest that oral NMN supplementation in the pre-aging stage might be an effective strategy to retard aging. We recommend further studies to unravel the underlying molecular mechanisms and comprehensive clinical trials to validate the effects of NMN on aging. |
| format |
article |
| author |
Kai-Min Niu Kai-Min Niu Kai-Min Niu Tongtong Bao Tongtong Bao Lumin Gao Meng Ru Yumeng Li Liang Jiang Changming Ye Shujin Wang Shujin Wang Xin Wu Xin Wu Xin Wu |
| author_facet |
Kai-Min Niu Kai-Min Niu Kai-Min Niu Tongtong Bao Tongtong Bao Lumin Gao Meng Ru Yumeng Li Liang Jiang Changming Ye Shujin Wang Shujin Wang Xin Wu Xin Wu Xin Wu |
| author_sort |
Kai-Min Niu |
| title |
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| title_short |
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| title_full |
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| title_fullStr |
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| title_full_unstemmed |
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase |
| title_sort |
impacts of short-term nmn supplementation on serum metabolism, fecal microbiota, and telomere length in pre-aging phase |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/be3fd8bacc5c472e85bb1e5bd63b62d0 |
| work_keys_str_mv |
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