Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.

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Autores principales:	Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be40aa23daf3428d9a9e7cfc26ff2f38
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spelling	oai:doaj.org-article:be40aa23daf3428d9a9e7cfc26ff2f382021-12-02T15:38:56ZTia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells10.1038/s41467-017-00454-22041-1723https://doaj.org/article/be40aa23daf3428d9a9e7cfc26ff2f382017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00454-2https://doaj.org/toc/2041-1723Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.Manuel D. Díaz-MuñozVladimir Yu. KiselevNicolas Le NovèreTomaz CurkJernej UleMartin TurnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manuel D. Díaz-Muñoz Vladimir Yu. Kiselev Nicolas Le Novère Tomaz Curk Jernej Ule Martin Turner Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
description	Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.
format	article
author	Manuel D. Díaz-Muñoz Vladimir Yu. Kiselev Nicolas Le Novère Tomaz Curk Jernej Ule Martin Turner
author_facet	Manuel D. Díaz-Muñoz Vladimir Yu. Kiselev Nicolas Le Novère Tomaz Curk Jernej Ule Martin Turner
author_sort	Manuel D. Díaz-Muñoz
title	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
title_short	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
title_full	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
title_fullStr	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
title_full_unstemmed	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
title_sort	tia1 dependent regulation of mrna subcellular location and translation controls p53 expression in b cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/be40aa23daf3428d9a9e7cfc26ff2f38
work_keys_str_mv	AT manuelddiazmunoz tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells AT vladimiryukiselev tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells AT nicolaslenovere tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells AT tomazcurk tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells AT jernejule tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells AT martinturner tia1dependentregulationofmrnasubcellularlocationandtranslationcontrolsp53expressioninbcells
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Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

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