Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo

Photoacoustic imaging has many advantages in ophthalmic application including high-resolution, requirement of no exogenous contrast agent, and noninvasive acquisition of both morphologic and functional information. However, due to the limited depth of focus of the imaging method and large curvature...

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Autores principales:	Huangxuan Zhao, Ke Li, Fan Yang, Wenhui Zhou, Ningbo Chen, Liang Song, Chuansheng Zheng, Zhicheng Liu, Chengbo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Institue of Optics and Electronics, Chinese Academy of Sciences 2021
Materias:	photoacoustic imaging ophthalmic imaging morphologic and functional information ophthalmic disease anterior segment Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/be477d7f502447c5a1ae332165a560ce
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spelling	oai:doaj.org-article:be477d7f502447c5a1ae332165a560ce2021-11-17T07:52:56ZCustomized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo2096-457910.29026/oea.2021.200017https://doaj.org/article/be477d7f502447c5a1ae332165a560ce2021-06-01T00:00:00Zhttp://www.oejournal.org/article/doi/10.29026/oea.2021.200017https://doaj.org/toc/2096-4579Photoacoustic imaging has many advantages in ophthalmic application including high-resolution, requirement of no exogenous contrast agent, and noninvasive acquisition of both morphologic and functional information. However, due to the limited depth of focus of the imaging method and large curvature of the eye, it remains a challenge to obtain high quality vascular image of entire anterior segment. Here, we proposed a new method to achieve high quality imaging of anterior segment. The new method applied a curvature imaging strategy based on only one time scanning, and hence is time efficient and more suitable for ophthalmic imaging compared to previously reported methods using similar strategy. A custom-built photoacoustic imaging system was adapted for ophthalmic application and a customized image processing method was developed to quantitatively analyze both morphologic and functional information in vasculature of the anterior segment. The results showed that the new method improved the image quality of anterior segment significantly compared to that of conventional high resolution photoacoustic imaging. More importantly, we applied the new method to study ophthalmic disease in an in vivo mouse model for the first time. The results verified the suitability and advantages of the new method for imaging the entire anterior segment and the numerous potentials of applying it in ophthalmic imaging in future.Huangxuan ZhaoKe LiFan YangWenhui ZhouNingbo ChenLiang SongChuansheng ZhengZhicheng LiuChengbo LiuInstitue of Optics and Electronics, Chinese Academy of Sciencesarticlephotoacoustic imagingophthalmic imagingmorphologic and functional informationophthalmic diseaseanterior segmentOptics. LightQC350-467ENOpto-Electronic Advances, Vol 4, Iss 6, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photoacoustic imaging ophthalmic imaging morphologic and functional information ophthalmic disease anterior segment Optics. Light QC350-467
spellingShingle	photoacoustic imaging ophthalmic imaging morphologic and functional information ophthalmic disease anterior segment Optics. Light QC350-467 Huangxuan Zhao Ke Li Fan Yang Wenhui Zhou Ningbo Chen Liang Song Chuansheng Zheng Zhicheng Liu Chengbo Liu Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
description	Photoacoustic imaging has many advantages in ophthalmic application including high-resolution, requirement of no exogenous contrast agent, and noninvasive acquisition of both morphologic and functional information. However, due to the limited depth of focus of the imaging method and large curvature of the eye, it remains a challenge to obtain high quality vascular image of entire anterior segment. Here, we proposed a new method to achieve high quality imaging of anterior segment. The new method applied a curvature imaging strategy based on only one time scanning, and hence is time efficient and more suitable for ophthalmic imaging compared to previously reported methods using similar strategy. A custom-built photoacoustic imaging system was adapted for ophthalmic application and a customized image processing method was developed to quantitatively analyze both morphologic and functional information in vasculature of the anterior segment. The results showed that the new method improved the image quality of anterior segment significantly compared to that of conventional high resolution photoacoustic imaging. More importantly, we applied the new method to study ophthalmic disease in an in vivo mouse model for the first time. The results verified the suitability and advantages of the new method for imaging the entire anterior segment and the numerous potentials of applying it in ophthalmic imaging in future.
format	article
author	Huangxuan Zhao Ke Li Fan Yang Wenhui Zhou Ningbo Chen Liang Song Chuansheng Zheng Zhicheng Liu Chengbo Liu
author_facet	Huangxuan Zhao Ke Li Fan Yang Wenhui Zhou Ningbo Chen Liang Song Chuansheng Zheng Zhicheng Liu Chengbo Liu
author_sort	Huangxuan Zhao
title	Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
title_short	Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
title_full	Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
title_fullStr	Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
title_full_unstemmed	Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
title_sort	customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
publisher	Institue of Optics and Electronics, Chinese Academy of Sciences
publishDate	2021
url	https://doaj.org/article/be477d7f502447c5a1ae332165a560ce
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Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo

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